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Table 2 Logistic regression, odds of cancer among women with BIRADS 4 mammograms, N= 464 a

From: The use of the Gail model, body mass index and SNPs to predict breast cancer among women with abnormal (BI-RADS 4) mammograms

  Age-adjusted Multivariate b
OR 95% CI P -value OR 95% CI P -value
SNP panel RR, log continuous scale 2.15 1.04 to 2.43 0.038 2.30 1.06 to 4.99 0.035
SNP panel RR, categories       
  <1.00 1.00 Reference    
  1.01 to 1.49 1.09 0.59 to 2.02 0.788    
  ≥1.50 1.60 0.84 to 3.04 0.149    
Gail RR, log continuous scale 1.11 0.69 to 1.78 0.660    
Gail absolute 5-yr risk, %       
  <1.67 1.00 Reference    
  ≥1.67 1.09 0.60 to 1.98 0.778    
Age, log continuous scale 1.05 1.03 to 1.07 <0.001 1.05 1.03 to 1.08 <0.001
Race/ethnicity       
  White 1.00 Reference 1.00 Reference
  African American/black 0.66 0.37 to 1.19 0.170 0.53 0.26 to 1.06 0.071
  Other 0.86 0.33 to 2.20 0.748 0.81 0.30 to 2.23 0.689
Age at menarche, yr       
<11 1.44 0.65 to 3.21 0.368 1.33 0.57 to 3.09 0.510
  12 to 13 1.67 0.85 to 3.30 0.139 1.50 0.73 to 3.06 0.266
  ≥14 1.00 Reference 1.00 Reference
  Unknown 0.77 0.29 to 2.07 0.608 0.83 0.28 to 2.41 0.729
Age at first live birth, yr       
  <30 1.00 Reference 1.00 Reference
  ≥30 1.58 0.81 to 3.08 0.183 1.37 0.66 to 2.87 0.400
  Nulliparous 1.09 0.58 to 2.06 0.780 1.06 0.54 to 2.08 0.867
  Missing data 1.60 0.17 to 15.0 0.680 2.26 0.22 to 23.6 0.497
First-degree relatives with breast cancer, n 1.48 0.86 to 2.57 0.160 1.62 0.90 to 2.90 0.106
Prior breast biopsy 0.73 0.43 to 1.24 0.242 0.82 0.47 to 1.46 0.508
Prior atypical hyperplasia 0.41 0.09 to 1.86 0.247 0.51 0.10 to 2.54 0.410
BMI, kg/m2, mean ± SD       
  <25 1.00 Reference 1.00 Reference
  25 to 29.9 1.68 0.81 to 3.47 0.161 1.86 0.86 to 4.05 0.116
  ≥30 1.94 0.99 to 3.81 0.054 2.20 1.05 to 4.58 0.036
  Missing data 1.85 0.87 to 3.93 0.111 1.80 0.81 to 3.99 0.147
  1. aBI-RADS, Breast Imaging-Reporting and Data System; BMI, Body mass index; CI, Confidence interval; OR, Odds ratio; RR, Relative risk; SD, Standard deviation; SNP, Single-nucleotide polymorphism. bMultivariate model includes log SNP RR, age, BMI, race/ethnicity, age at menarche, age of first birth, family history of breast cancer, breast biopsy and atypical hyperplasia.