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Table 2 Logistic regression, odds of cancer among women with BIRADS 4 mammograms, N  = 464 a

From: The use of the Gail model, body mass index and SNPs to predict breast cancer among women with abnormal (BI-RADS 4) mammograms

 

Age-adjusted

Multivariate b

OR

95% CI

P -value

OR

95% CI

P -value

SNP panel RR, log continuous scale

2.15

1.04 to 2.43

0.038

2.30

1.06 to 4.99

0.035

SNP panel RR, categories

      

  <1.00

1.00

Reference

   

  1.01 to 1.49

1.09

0.59 to 2.02

0.788

   

  ≥1.50

1.60

0.84 to 3.04

0.149

   

Gail RR, log continuous scale

1.11

0.69 to 1.78

0.660

   

Gail absolute 5-yr risk, %

      

  <1.67

1.00

Reference

   

  ≥1.67

1.09

0.60 to 1.98

0.778

   

Age, log continuous scale

1.05

1.03 to 1.07

<0.001

1.05

1.03 to 1.08

<0.001

Race/ethnicity

      

  White

1.00

Reference

1.00

Reference

  African American/black

0.66

0.37 to 1.19

0.170

0.53

0.26 to 1.06

0.071

  Other

0.86

0.33 to 2.20

0.748

0.81

0.30 to 2.23

0.689

Age at menarche, yr

      

<11

1.44

0.65 to 3.21

0.368

1.33

0.57 to 3.09

0.510

  12 to 13

1.67

0.85 to 3.30

0.139

1.50

0.73 to 3.06

0.266

  ≥14

1.00

Reference

1.00

Reference

  Unknown

0.77

0.29 to 2.07

0.608

0.83

0.28 to 2.41

0.729

Age at first live birth, yr

      

  <30

1.00

Reference

1.00

Reference

  ≥30

1.58

0.81 to 3.08

0.183

1.37

0.66 to 2.87

0.400

  Nulliparous

1.09

0.58 to 2.06

0.780

1.06

0.54 to 2.08

0.867

  Missing data

1.60

0.17 to 15.0

0.680

2.26

0.22 to 23.6

0.497

First-degree relatives with breast cancer, n

1.48

0.86 to 2.57

0.160

1.62

0.90 to 2.90

0.106

Prior breast biopsy

0.73

0.43 to 1.24

0.242

0.82

0.47 to 1.46

0.508

Prior atypical hyperplasia

0.41

0.09 to 1.86

0.247

0.51

0.10 to 2.54

0.410

BMI, kg/m2, mean ± SD

      

  <25

1.00

Reference

1.00

Reference

  25 to 29.9

1.68

0.81 to 3.47

0.161

1.86

0.86 to 4.05

0.116

  ≥30

1.94

0.99 to 3.81

0.054

2.20

1.05 to 4.58

0.036

  Missing data

1.85

0.87 to 3.93

0.111

1.80

0.81 to 3.99

0.147

  1. aBI-RADS, Breast Imaging-Reporting and Data System; BMI, Body mass index; CI, Confidence interval; OR, Odds ratio; RR, Relative risk; SD, Standard deviation; SNP, Single-nucleotide polymorphism. bMultivariate model includes log SNP RR, age, BMI, race/ethnicity, age at menarche, age of first birth, family history of breast cancer, breast biopsy and atypical hyperplasia.