Skip to main content

Table 1 Identification of CTCs and BM-DTCs in BC PDX lines and previously reported presence of LM

From: Circulating and disseminated tumor cells from breast cancer patient-derived xenograft-bearing mice as a novel model to study metastasis

PDX line CTC detection rate (%) Number of CTCs per 20 K nucleated cells (≈20 μl of blood) BM-DTC detection rate (%) Number of BM-DTCs per 2 × 10 6 BM cells LM rate [26] (%)
BCM-3107* 1/4 (25) 7 1/2 (50) 1 0
BCM-3143 0/2 (0) 0 0/2 (0) 0 0
BCM-3204* 2/4 (50)Cl 3-43 0/2 (0) 0 29
BCM-3561* 2/4 (50) 1 ND ND 0
BCM-3613* 1/3 (33) 7 0/2 (0) 0 24
BCM-3807 0/4 (0) 0 1/2 (50) 29 0
BCM-3887* 3/4 (75)Cl 3-92 1/5 (20) <1 14
BCM-3963* 1/6 (17) 7 0/4 (0) 0 14
BCM-4195 0/2 (0) 0 0/2 (0) 0 0
BCM-4272* 3/3 (100) <1-25 4/6 (67)Cl <1-132 29
BCM-4664* 1/3 (33) 2 ND ND 0
BCM-4888* 5/5 (100)Cl 3-28 0/4 (0) 0 67
BCM-5097 3/6 (50)Cl 10-91 3/5 (60) 12-30 36
BCM-5156 3/5 (60) 1-28 1/2 (50) 2 0
BCM-5438 2/2 (100) 2-3 2/2 (100) 4-67 0
BCM-5471 3/6 (50)Cl 1-10 2/4 (50)Cl <1-6 33
BCM-5998 5/7 (71) <1-27 6/8 (75)Cl 1-40 0
BCM-6257 3/3 (100)Cl 3-4 2/3 (67)Cl 22-39 6
  1. BC, breast cancer; BM, bone marrow; BM-DTCs, disseminated tumor cells in bone marrow; CTC,s circulating tumor cells, LM, lung metastasis, ND, not determined, PDX, patient-derived xenograft. Cl represents presence of CTCs and BM-DTCs in clusters. * indicates the lines with published Affymetrix data.