Circulating and disseminated tumor cells from breast cancer patient-derived xenograft-bearing mice as a novel model to study metastasis

Table 1 Identification of CTCs and BM-DTCs in BC PDX lines and previously reported presence of LM

PDX line	CTC detection rate (%)	Number of CTCs per 20 K nucleated cells (≈20 μl of blood)	BM-DTC detection rate (%)	Number of BM-DTCs per 2 × 10 ⁶ BM cells	LM rate [26] (%)
BCM-3107*	1/4 (25)	7	1/2 (50)	1	0
BCM-3143	0/2 (0)	0	0/2 (0)	0	0
BCM-3204*	2/4 (50)^Cl	3-43	0/2 (0)	0	29
BCM-3561*	2/4 (50)	1	ND	ND	0
BCM-3613*	1/3 (33)	7	0/2 (0)	0	24
BCM-3807	0/4 (0)	0	1/2 (50)	29	0
BCM-3887*	3/4 (75)^Cl	3-92	1/5 (20)	<1	14
BCM-3963*	1/6 (17)	7	0/4 (0)	0	14
BCM-4195	0/2 (0)	0	0/2 (0)	0	0
BCM-4272*	3/3 (100)	<1-25	4/6 (67)^Cl	<1-132	29
BCM-4664*	1/3 (33)	2	ND	ND	0
BCM-4888*	5/5 (100)^Cl	3-28	0/4 (0)	0	67
BCM-5097	3/6 (50)^Cl	10-91	3/5 (60)	12-30	36
BCM-5156	3/5 (60)	1-28	1/2 (50)	2	0
BCM-5438	2/2 (100)	2-3	2/2 (100)	4-67	0
BCM-5471	3/6 (50)^Cl	1-10	2/4 (50)^Cl	<1-6	33
BCM-5998	5/7 (71)	<1-27	6/8 (75)^Cl	1-40	0
BCM-6257	3/3 (100)^Cl	3-4	2/3 (67)^Cl	22-39	6

BC, breast cancer; BM, bone marrow; BM-DTCs, disseminated tumor cells in bone marrow; CTC,s circulating tumor cells, LM, lung metastasis, ND, not determined, PDX, patient-derived xenograft. ^Cl represents presence of CTCs and BM-DTCs in clusters. * indicates the lines with published Affymetrix data.

ISSN: 1465-542X