Cancer progression by breast tumors with Pit-1-overexpression is blocked by inhibition of metalloproteinase (MMP)-13

Table 1 Relationships between MMP-1 and MMP-13 expression by each cell type and Pit-1 global expression in 110 breast carcinomas

Factor	N	Pit-1 median (range)	P value
MMP-1
Tumor cell			0.004
negative	5	5.6 (0 – 13.1)
positive	105	38.3 (0 – 194.5)
Fibroblast			0.017
negative	15	21.5 (0 – 89.6)
positive	95	27.4 (0 – 194.5)
MICs			0.068
negative	30	31.8 (0 – 124.5)
positive	80	36.7 (0 – 194.5)
MMP-13
Tumor cell			0.0001
negative	26	12.2 (0 – 135.6)
positive	84	45.1 (0 – 194.5)
Fibroblast			0.029
negative	60	32.5 (0 – 194.5)
positive	50	43.9 (0 – 143.2)
MICs			0.120
negative	82	33.8 (0 – 194.5)
positive	28	45.0 (0 – 132.3)

MMP-1, matrix metalloproteinase-1; MMP-13, matrix metalloproteinase-13; Pit-1, POU class 1 homeobox 1; MICs: mononuclear inflammatory cells.

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