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Table 1 Relationships between MMP-1 and MMP-13 expression by each cell type and Pit-1 global expression in 110 breast carcinomas

From: Cancer progression by breast tumors with Pit-1-overexpression is blocked by inhibition of metalloproteinase (MMP)-13

Factor N Pit-1 median (range) P value
MMP-1    
Tumor cell    0.004
negative 5 5.6 (0 – 13.1)  
positive 105 38.3 (0 – 194.5)  
Fibroblast    0.017
negative 15 21.5 (0 – 89.6)  
positive 95 27.4 (0 – 194.5)  
MICs    0.068
negative 30 31.8 (0 – 124.5)  
positive 80 36.7 (0 – 194.5)  
MMP-13    
Tumor cell    0.0001
negative 26 12.2 (0 – 135.6)  
positive 84 45.1 (0 – 194.5)  
Fibroblast    0.029
negative 60 32.5 (0 – 194.5)  
positive 50 43.9 (0 – 143.2)  
MICs    0.120
negative 82 33.8 (0 – 194.5)  
positive 28 45.0 (0 – 132.3)  
  1. MMP-1, matrix metalloproteinase-1; MMP-13, matrix metalloproteinase-13; Pit-1, POU class 1 homeobox 1; MICs: mononuclear inflammatory cells.