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Figure 8 | Breast Cancer Research

Figure 8

From: Humanization of the mouse mammary gland by replacement of the luminal layer with genetically-engineered preneoplastic human cells

Figure 8

DCIS formation 3 weeks after intraductal injection of 4G-shp53-PI3K tumor cells. A. Composite image showing human cells expressing CFP scattered throughout the gland. B. Enlarged images; the right panel shows alternating clusters of yellow and green cells. C. H&E stain and immunohistochemistry showing ERα+, Ki67+ DCIS (the PGR staining is negative in the tumor cell nuclei relative to controls on the slide). Scale bars A & B 1 mm, C 100 μm.

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