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Table 5 Postneonatal outcomes of children exposed to chemotherapy in utero

From: Outcomes of children exposed in uteroto chemotherapy for breast cancer

Reported outcome

n / N (%)

≥4 cycles of anthracycline-based in utero chemotherapy exposure, n / N (%)

Population prevalence, % [reference]

Child considered healthy

49/50 (98)

–

–

Developmental milestone delays

6/50 (12)

2/6 (33)

10 [22]

Difficulties in schoola

4/37 (11)

3/4 (75)

6-11 [22]

Reported health concerns

31/50 (62)

19/31 (61)

–

Allergies/eczema

18/50 (36)

12/18 (67)

11 to 25 [22]

Asthma/breathing

5/50 (10)

4/5 (80)

13 [22]

Vision

8/50 (16)

5/8 (63)

14 [22]

Heart murmurb

1/50 (2)

–

1.3 [23]

“Lazy eye”

2/50 (4)

1/2 (50)

1.6 to 3.6 [24]

Absence seizuresc

1/50 (2)

1/1 (100)

<1 [25]

ENTd

4/50 (8)

3/4 (75)

HL, <1; ROM, 18 to 26d [26]

GERDe

2/50 (6)

2/2 (100)

5 to 67f [27]

  1. aReading delay (n = 3) and difficulty with attention span (n = 1); data are for 37 school-aged children. bResolved by age 1 year. cPossibly hereditary. dEar, nose, and throat (ENT) includes recurrent otitis media (ROM; n = 2), sinus problems (n = 1) and hearing deficit (HL; n = 1). eGastroesophageal reflux disease. fVaries according to age.