Table 4 Neonatal complications of children exposed to chemotherapy in utero
From: Outcomes of children exposed in uteroto chemotherapy for breast cancer
Complication | n (%) | ≥4 cycles of anthracycline-based in utero chemotherapy exposure, n | <4 cycles of anthracycline-based in utero chemotherapy exposure, n | Preterm, n (<37 wk) | Term, n (≥37 wk) |
|---|---|---|---|---|---|
Any neonatal complications at delivery (N = 63a) | 21 (33) | 13 | 8 | 14 | 7 |
Breathing difficulties | 11 (17) | 9 | 2 | 7 | 4 |
Subarachnoid hemorrhage | 1 (2) | 1 | 0 | 1 | – |
Jaundice | 3 (5) | 2 | 1 | 2 | 1 |
Low heart rate | 2 (3) | 1 | 1 | 1 | 1 |
Hypoglycemia | 2 (3) | 0 | 2 | 1 | 1 |
Abnormal temperature | 2 (3) | 2 | 0 | 1 | 1 |
NICU/hospitalizations (N = 63a) | 9 (14) | 5 | 4 | 4 | 5 |
Prolonged NICU stayb (>1 mo) | 2 (3) | 0 | 2 | 2c | – |
Temporary hospital or NICU stay (≤14 days) | 7 (11) | 5 | 2 | 2 | 5 |