Gene variations in oestrogen pathways, CYP19A1, daily 17β-estradiol and mammographic density phenotypes in premenopausal women

Table 2 Associations between two CYP19A1 single-nucleotide polymorphisms ( rs749292 , rs7172156 ) and 17β-estradiol

*CYP19A1* SNPs	Location	Frequencies	Genotype	β-value (95% CI)	P -value
rs749292	Intron
Salivary 17β-estradiol		0.283	AA	Reference
		0.457	Aa	2.73 (−0.22, 5.68)	0.069
		0.26	aa	3.79 (0.39, 7.20)	0.029
P-value for trend					0.026
Serum 17β-estradiol			AA	Reference
			Aa	6.77 (−13.4, 26.9)	0.509
			aa	0.73 (−22.8, 24.2)	0.951
P-value for trend					0.905
rs7172156	Intron
Salivary 17β-estradiol		0.406	AA	Reference
		0.444	Aa	−0.10 (−2.76, 2.56)	0.939
		0.15	aa	−6.96 (−10.6, −3.32)	<0.001
P-value for trend					0.002
Serum 17β-estradiol			AA	Reference
			Aa	−3.38 (−22.1, 15.3)	0.722
			aa	−12.4 (−38.1, 13.2)	0.340
P-value for trend					0.365

Multivariable linear regression model adjusted for age, parity and body mass index. β: Estimated slope coefficient (for example, change in response) from reference (AA) to Aa and aa; CI, Confidence interval; SNP, Single-nucleotide polymorphism. Salivary midmenstrual estradiol is the average of aligned menstrual estradiol levels from days −7 to +6. Serum 17β-estradiol was measured from early follicular phase days 1 to 5.

ISSN: 1465-542X