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Figure 5 | Breast Cancer Research

Figure 5

From: Elafin is downregulated during breast and ovarian tumorigenesis but its residual expression predicts recurrence

Figure 5

Residual elafin-positive tumor cells are prognostic of poor DSS in patients with stage I/II ovarian cancer. (A) Representative photomicrographs of elafin immunohistochemical (IHC) staining in invasive ovarian carcinoma demonstrating (i) negative (elafin score = 0) and (ii) positive (elafin score >0) staining. (B) Frequency distribution illustrating the percentage of cases falling into each categorical score over the range 0 to 8. The dashed line represents the cutoff used in this analysis. (C) Kaplan-Meier survival analysis of overall survival (OS), disease-specific survival (DSS) and recurrence-free survival (RFS) in elafin-positive and -negative ovarian cancer cases. The top panel represents all the patients, and for the middle and bottom panels, the patients were grouped into those with stage I/II and III/IV cancer, respectively and subjected to the three different survival analyses. Significance calculated by rank-sum test.

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Breast Cancer Research

ISSN: 1465-542X

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