N tumors with morphology (MAF) | Other morphology | Tumors with morphology | |||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Subtype | Sample | SNP | Locus | Position b | Nearby gene | Ref c | Eff d | Reported e | Present | Other | Unknown | Number unaffected (MAF) | HR (95% CI) | P -value | HR (95% CI) | P -value | P het-value f |
Ductal | BRCA1 carriers | rs10069690 | 5p15.33 | 1332790 | TERT | G | A | Yes | 3,155 (0.29) | 847 (0.30) | 3,783 (0.30) | 7,449 (0.26) | 1.23 (1.11 to 1.36) | 7.3 × 10−5 | 1.20 (1.14 to 1.26) | 2.0 × 10−11 | 0.67 |
rs11155803 | 6q25.1 | 151987362 | C6orf97 | A | G | Yes | 3,159 (0.36) | 848 (0.35) | 3,786 (0.36) | 7,452 (0.32) | 1.13 (1.03 to 1.25) | 0.01 | 1.17 (1.11 to 1.23) | 4.6 × 10−10 | 0.58 | ||
rs10252939 | 7q36 | 155587448 | A | G | No | 3,159 (0.28) | 849 (0.33) | 3,789 (0.29) | 7,455 (0.32) | 1.08 (0.98 to 1.19) | 0.14 | 0.87 (0.82 to 0.91) | 1.0 × 10−7 | 2.7 × 10−4 | |||
rs8100241 | 19p13.11 | 17253894 | ANKLE1 | G | A | Yes | 3,137 (0.48) | 844 (0.49) | 3,777 (0.47) | 7,420 (0.52) | 0.87 (0.79 to 0.95) | 2.8 × 10−3 | 0.84 (0.8 to 0.88) | 1.5 × 10−13 | 0.51 | ||
BRCA2 carriers | rs2162540 | 10q26 | 123342126 | FGFR2 | A | G | Yes | 1,728 (0.45) | 458 (0.44) | 2,038 (0.44) | 3,783 (0.38) | 1.24 (1.08 to 1.42) | 1.8 × 10−3 | 1.30 (1.21 to 1.39) | 3.1 × 10−14 | 0.55 | |
rs1362548 | 16q12.1 | 51121452 | TOX3 | C | G | Yes | 1,770 (0.3) | 473 (0.32) | 2,087 (0.31) | 3,881 (0.26) | 1.32 (1.15 to 1.51) | 4.8 × 10−5 | 1.23 (1.15 to 1.32) | 7.3 × 10−9 | 0.36 | ||
Lobular | BRCA2 carriers | rs2186703 | 11q23.3 | 115265717 | RPL15P15 | A | C | No | 188 (0.07) | 2,055 (0.03) | 2,087 (0.04) | 3,881 (0.03) | 1.09 (0.93 to 1.27) | 0.29 | 2.54 (1.78 to 3.62) | 2.8 × 10−7 | 1.5 × 10−5 |
rs55998524 | Xp11.23 | 51082075 | NUDT10 | C | G | No | 188 (0.11) | 2,054 (0.05) | 2,086 (0.06) | 3,880 (0.05) | 0.96 (0.83 to 1.1) | 0.54 | 2.42 (1.77 to 3.32) | 3.6 × 10−8 | 7.0 × 10−8 |