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Table 3 Comparisons between the associations of 74 breast cancer susceptibility loci in BRCA1 carriers, in BRCA2 carriers, and in population-based studies a

From: Associations of common breast cancer susceptibility alleles with risk of breast cancer subtypes in BRCA1 and BRCA2 mutation carriers

  

BRCA1 carriers

BRCA2 carriers

  

Overall

ER-positive

ER-negative

Overall

ER-positive

ER-negative

BRCA2 carriers

Overall

0.46 (0.25 to 0.62)

     

ER-positive

 

0.67 (0.52 to 0.78)

0.13 (−0.10 to 0.35)

   

ER-negative

 

0.10 (−0.13 to 0.33)

0.46 (0.25 to 0.62)

   

BCAC

Overall

0.43 (0.22 to 0.60)

  

0.63 (0.47 to 0.75)

  

ER-positive

 

0.61 (0.45 to 0.74)

0.16 (−0.07 to 0.38)

 

0.69 (0.55 to 0.79)

0.13 (−0.11 to 0.35)

ER-negative

 

0.34 (0.12 to 0.53)

0.59 (0.42 to 0.72)

 

0.39 (0.17 to 0.57)

0.28 (0.05 to 0.48)

  1. aER, Estrogen receptor. Data are intraclass correlation coefficients and 95% confidence intervals, which describe associations with overall breast cancer as well as by ER status. Data are derived from published studies by the Breast Cancer Association Consortium (BCAC).