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Table 4 Numbers of total, proliferative and apoptotic CTCs in serial samples during the dormancy period for DC with a prolonged disease-free status (n = 8)

From: Evaluation of proliferation and apoptosis markers in circulating tumor cells of women with early breast cancer who are candidates for tumor dormancy

Patient number Dormancy period (yrs) Test no/(time since surgery yrs) Status Total CTCs Dormant a/Total Nondormant d/Total (%) Proliferative b/Nondormant d(%) Apoptotic c/Nondormant d(%)
9 8 1 (5) DF 1 100 0 0 0
2 (5.5) DF 0 0 0 0 0
3 (6) DF 1 100 0 0 0
4 (6.5) DF 0 0 0 0 0
5 (7) DF 0 0 0 0 0
6 (7.5) DF 0 0 0 0 0
7 (8) DF 0 0 0 0 0
10 13 1 (5) DF 1.5 100 0 0 0
2 (8) DF 0 0 0 0 0
3 (11) DF 5 60 40 100 0
4 (12) DF 0.5 100 0 0 0
5 (13) DF 0.5 0 100 100 0
11 10 1 (7) DF 1 0 100 0 100
2 (8) DF 1 0 100 0 100
3 (9) DF 2 50 50 100 0
4 (10) DF 2 100 0 0 0
12 13 1 (5) DF 2 75 25 100 0
2 (5.5) DF 3.5 100 0 0 0
3 (9.5) DF 22 75 25 25 75
4 (10.5) DF 1 0 100 0 100
5 (11.5) DF 0 0 0 0 0
6 (12) DF 0 0 0 0 0
7 (13) DF 0 0 0 0 0
13 10.5 1 (5) DF 0.5 100 0 0 0
2 (9) DF 1 100 0 0 0
3 (10.5) DF 0 0 0 0 0
14 10.5 1 (5) DF 0 0 0 0 0
2 (6) DF 0.5 100 0 0 0
3 (10) DF 0 0 0 0 0
15 8 1 (5) DF 0.5 100 0 0 0
2 (5.5) DF 0 0 0 0 0
3 (6) DF 0.5 100 0 0 0
4 (8) DF 0 0 0 0 0
16 12 1 (10) DF 0 0 0 0 0
2 (11) DF 1 100 0 0 0
3 (12) DF 31 82 18 0 100
  1. aKi67(-)/M30(-) CTCs, bKi67(+)/M30(-) CTCs, cKi67(-)/M30(+), dKi67(+)/M30(-) or Ki67(-)/M30(+) CTCs. CTCs, circulating tumor cells; DC, dormancy candidates; DF, disease-free.