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Table 4 Androgen effects on tumor growth (induced by chemical carcinogens)

From: The role of androgens in experimental rodent mammary carcinogenesis

Reference Animal model Type of androgen Dose a Tumor growth
7,12-Dimethylbenz(a)anthracene (using androgens)   
Young and colleagues [60] SD ratsb T 1.2 to 6?mg weekly ?
   DHT 1.2 to 6?mg weekly  
Heise and Gorlich [61] SD rats TP 6 to 180?mg/kg weekly ? (low dose only)
Teller and colleagues [62] SD rats MDTP and TP Total of 480?mg for 8?weeks ?
Shimkin and colleagues [16] SD/Wistar rats DP 200?mg weekly for 6?weeks No effect
Teller and colleagues [63] SD rats MDTP and TP 3.75 to 60?mg weekly for 8?weeks ?
Teller and colleagues [64] SD rats MDTP 60?mg weekly for 8?weeks ?
Mobbs [67] SD rats TP 10 or 50?mg/kg weekly or a single 60?mg pellet ? (high dose only)
Griswold and Green [68] SD rats MDTP and TP 10?mg/kg daily for 20?days ?
Briziarelli and colleagues [69] SD rats FBTA 2 or 4?mg daily for 30?days ?
Takahashi and colleagues [70] SD rats MDTP and TP 6?mg weekly ?
Quadri and colleagues [71] SD rats DmP 0.5?mg daily for 3?weeks ?
Horn and colleagues [72] Inbred rats Calsterone 10?mg daily for 2 to 3?weeks ?
Costlow and colleagues [73] SD rats TP 8?mg weekly ?
Zava and McGuire [74] SD rats TP 2.4?mg weekly ?
Teller and colleagues [65] SD rats MDTP 200?mg/kg weekly for 5?weeks ?
Teller and colleagues [66] SD rats MDTP 3 to 100?mg/kg weekly for 4?weeks ? (dose dependent)
Dauvois and colleagues [51] SD rats DHT 3?cm silastic implant (30/100, DHT/cholesterol, w/w) ?
Boccuzzi and colleagues [75] SD rats DHEA 4?mg daily for 21?days ?
Boccuzzi and colleagues [76] SD rats DHT 25??g DHT daily for 20?days ?
Gatto and colleagues [77] SD rats DHEA 4?mg daily for 20?days ?
Methylcholanthrene (using androgens)   
Ercoli and Briziarelli [79] SD rats DHT or DHT enol ethers 2?mg daily for 30?days ?
Shimkin and colleagues [16] SD/Wistar rats DP 200?mg/kg weekly for 6?weeks No effect
7,12-Dimethylbenz(a)anthracene (using anti-androgens)   
Spinola and colleagues [78] SD rats Flutamide 10?mg daily for 20?days ?
Boccuzzi and colleagues [76] SD rats Flutamide 2?mg daily for 20?days ?
  1. DHEA, dehydroepiandrosterone; DHT, dihydrotestosterone; DmP, dromostanolone propionate; DP, drostanolone propionate; FBTA, 9?-fluoro-11?-hydroxybenzo[d,e] testosterone 17-acetate; MDTP, 2?-methyl-DHT propionate; SD, Sprague?Dawley; T, testosterone; TP, testosterone propionate. aSome doses are shown as weekly doses calculated based on the dosing regime in the original article. bFemale rats unless otherwise specified.