Skip to main content

Table 2 Androgen effects on tumor incidence (induced by chemical carcinogens)

From: The role of androgens in experimental rodent mammary carcinogenesis

Reference

Animal model

Type of androgen

Dose a

Duration

Incidence

7,12-Dimethylbenz(a)anthracene

    

Briziarelli [40]

SD ratsb

TP

0.01, 0.05, 0.5, 1 or 1.5?mg daily

30?days

? (at doses of 0.5 to 1.5?mg)c

Briziarelli [41]

SD rats

TP

0.13, 0.26, 0.4 or 10.5?mg daily

10?days

? (0.26 only)

Li and colleagues [42]

SD rats

DHEA

(Not described)

Implant

?

Luo and colleagues [43]

SD rats

DHEA

5, 10 or 20?mg daily

9?months

?

Kohama and colleagues [44]

Wistar rats

DHEA or TE

150?mg/kg DHEA or 60?mg/kg TE weekly

22?weeks

?

Methylcholanthrene

     

Shay and colleagues [15]

Wistar rats

T

37 or 75?mg

Implant

?

Shay and colleagues [45]

Wistar rats

T

75?mg

Implant

?

N -Nitroso- N -methylurea

     

Lubet and colleagues [46]

SD rats

DHEA

5, 24, 120, 600 or 2,000?mg/kg DHEA in diet

109?days

? (600/2,000)

  1. DHEA, dehydroepiandrosterone; SD, Sprague?Dawley; T, testosterone; TE, testosterone enanthate; TP, testosterone propionate. aSome doses are shown as weekly doses calculated based on the dosing regime in the original article. bFemale rats unless otherwise specified. cWhen TP treatment started 10 or 20?days after 7,12-dimethylbenz(a)anthracene but not later.