Skip to main content

Table 2 Androgen effects on tumor incidence (induced by chemical carcinogens)

From: The role of androgens in experimental rodent mammary carcinogenesis

Reference Animal model Type of androgen Dose a Duration Incidence
7,12-Dimethylbenz(a)anthracene     
Briziarelli [40] SD ratsb TP 0.01, 0.05, 0.5, 1 or 1.5?mg daily 30?days ? (at doses of 0.5 to 1.5?mg)c
Briziarelli [41] SD rats TP 0.13, 0.26, 0.4 or 10.5?mg daily 10?days ? (0.26 only)
Li and colleagues [42] SD rats DHEA (Not described) Implant ?
Luo and colleagues [43] SD rats DHEA 5, 10 or 20?mg daily 9?months ?
Kohama and colleagues [44] Wistar rats DHEA or TE 150?mg/kg DHEA or 60?mg/kg TE weekly 22?weeks ?
Methylcholanthrene      
Shay and colleagues [15] Wistar rats T 37 or 75?mg Implant ?
Shay and colleagues [45] Wistar rats T 75?mg Implant ?
N -Nitroso- N -methylurea      
Lubet and colleagues [46] SD rats DHEA 5, 24, 120, 600 or 2,000?mg/kg DHEA in diet 109?days ? (600/2,000)
  1. DHEA, dehydroepiandrosterone; SD, Sprague?Dawley; T, testosterone; TE, testosterone enanthate; TP, testosterone propionate. aSome doses are shown as weekly doses calculated based on the dosing regime in the original article. bFemale rats unless otherwise specified. cWhen TP treatment started 10 or 20?days after 7,12-dimethylbenz(a)anthracene but not later.