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Figure 2 | Breast Cancer Research

Figure 2

From: A novel phosphatidylinositol 3-kinase (PI3K) inhibitor directs a potent FOXO-dependent, p53-independent cell cycle arrest phenotype characterized by the differential induction of a subset of FOXO-regulated genes

Figure 2

Focused toxicity and safety assessment of ETP-45658. (A) Analysis of BioFunctions using Ingenuity Pathway Tox Analysis comparing ETP-45658 vs DMSO (sorted by P value where Y axis represents -log (P value). (B) Analysis of canonical pathways using Ingenuity Pathway Tox Analysis comparing ETP-45658 vs DMSO (sorted by P value). Y axis represents -log (P value). The line graph indicates the canonical pathway ratio (number of molecules in a given pathway that meet cut-off criteria, divided by total number of molecules that make up that pathway). None of the canonical pathways have been identified as significant suggesting little or no toxicity of treatment.

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Breast Cancer Research

ISSN: 1465-542X

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