Figure 6From: Modulation of tumor fatty acids, through overexpression or loss of thyroid hormone responsive protein spot 14 is associated with altered growth and metastasisInfluence of S14 on tumor metastasis and gene expression. (A) Percent of mice with visible lung metastases upon H&E examination in polyomavirus middle T antigen (PyMT) (11/17) or PyMT/S14−/− (S14−/−; 8/12) mice; Fisher’s exact P-value = 1.0. (B) Number of visible lung lesions in PyMT or S14−/− mice. Fisher’s exact P-value = 0.9. (C) Percent of mice with visible lung metastases upon H&E examination in Neu (6/17) or Neu/S14 (1/15) mice. Fisher’s exact P-value = 0.09. Representative metastatic lesions in lungs from Neu (D), Neu/S14 (E), PyMT (F) and S14−/−(G) mice. (D) and (E) were captured at 20x magnification; (F) and (G) were captured at 40x magnification. (H) Expression of genes associated with mammary epithelial cell differentiation in primary tumors from Neu (N; black) and Neu/S14 (N/S; red) mice. (I) Csn2, Csn1s2a, and Krt18 expression in tumors from PyMT and PyMT/S14−/− mice. Tumors from PyMT/S14−/− (S) mice are categorized as solid (S-sol; green) or cystic (S-cyst; blue). ‡P <0.1; *P <0.05; **P ≤0.01; ns = not significant.Back to article page