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Figure 6 | Breast Cancer Research

Figure 6

From: Modulation of tumor fatty acids, through overexpression or loss of thyroid hormone responsive protein spot 14 is associated with altered growth and metastasis

Figure 6

Influence of S14 on tumor metastasis and gene expression. (A) Percent of mice with visible lung metastases upon H&E examination in polyomavirus middle T antigen (PyMT) (11/17) or PyMT/S14−/− (S14−/−; 8/12) mice; Fisher’s exact P-value = 1.0. (B) Number of visible lung lesions in PyMT or S14−/− mice. Fisher’s exact P-value = 0.9. (C) Percent of mice with visible lung metastases upon H&E examination in Neu (6/17) or Neu/S14 (1/15) mice. Fisher’s exact P-value = 0.09. Representative metastatic lesions in lungs from Neu (D), Neu/S14 (E), PyMT (F) and S14−/−(G) mice. (D) and (E) were captured at 20x magnification; (F) and (G) were captured at 40x magnification. (H) Expression of genes associated with mammary epithelial cell differentiation in primary tumors from Neu (N; black) and Neu/S14 (N/S; red) mice. (I) Csn2, Csn1s2a, and Krt18 expression in tumors from PyMT and PyMT/S14−/− mice. Tumors from PyMT/S14−/− (S) mice are categorized as solid (S-sol; green) or cystic (S-cyst; blue). ‡P <0.1; *P <0.05; **P ≤0.01; ns = not significant.

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