|
SNP
| |
Minor
|
Nulliparous
|
(n = 63)
| | |
Parous
|
(n = 219)
| | | |
|---|
|
(major/minor allele)
|
Gene
|
allele frequency
|
N (WW/WV/VV)
|
Beta (SE)
|
P
|
P
ACT
*
|
N (WW/WV/VV)
|
Beta (SE)
|
P
|
P
ACT
*
|
P for interaction †
|
|---|
|
rs2077647 (T/C)
|
ESR1
|
0.49
|
18/30/15
|
3.92 (1.06)
|
0.0005
|
0.006
|
56/118/43
|
−0.40 (0.63)
|
0.53
|
>0.99
|
0.003
|
|
rs9605030 (C/T)
|
COMT
|
0.14
|
40/21/2
|
4.47 (1.42)
|
0.0025
|
0.043
|
166/48/4
|
0.69 (0.88)
|
0.44
|
>0.99
|
0.011
|
|
rs5933863 (G/A)
|
ARSC
|
0.15
|
46/17/0
|
1.26 (1.88)
|
0.51
|
0.75
|
152/62/5
|
2.00 (0.81)
|
0.014
|
0.027
|
0.82
|
- ¶Based on linear regression model adjusting for age and BMI (kg/m2) at time of on-EPT mammogram, time interval and BMI change between the two mammograms, and mammographic density of on-EPT mammogram. Additive genetic model was used. *Multiple testing corrected P value; P ACT (P values adjusted for correlated tests) within each gene was calculated using the methods by Conneely and Boehnke [33]. †P values for interaction were not corrected for multiple testing. SNP, single nucleotide polymorphisms; EPT, estrogen and progestin combined therapy; SE, standard error; BMI, body mass index.
