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Table 4 SNPs that are statistically significantly associated with EPT-associated mammographic density change in either nulliparous (n = 63) or parous (n = 219) women after correcting for multiple testing at gene level

From: Hormone metabolism pathway genes and mammographic density change after quitting estrogen and progestin combined hormone therapy in the California Teachers Study

SNP   Minor Nulliparous (n = 63)    Parous (n = 219)    
(major/minor allele) Gene allele frequency N (WW/WV/VV) Beta (SE) P P ACT * N (WW/WV/VV) Beta (SE) P P ACT * P for interaction
rs2077647 (T/C) ESR1 0.49 18/30/15 3.92 (1.06) 0.0005 0.006 56/118/43 −0.40 (0.63) 0.53 >0.99 0.003
rs9605030 (C/T) COMT 0.14 40/21/2 4.47 (1.42) 0.0025 0.043 166/48/4 0.69 (0.88) 0.44 >0.99 0.011
rs5933863 (G/A) ARSC 0.15 46/17/0 1.26 (1.88) 0.51 0.75 152/62/5 2.00 (0.81) 0.014 0.027 0.82
  1. Based on linear regression model adjusting for age and BMI (kg/m2) at time of on-EPT mammogram, time interval and BMI change between the two mammograms, and mammographic density of on-EPT mammogram. Additive genetic model was used. *Multiple testing corrected P value; P ACT (P values adjusted for correlated tests) within each gene was calculated using the methods by Conneely and Boehnke [33]. P values for interaction were not corrected for multiple testing. SNP, single nucleotide polymorphisms; EPT, estrogen and progestin combined therapy; SE, standard error; BMI, body mass index.