Hormone metabolism pathway genes and mammographic density change after quitting estrogen and progestin combined hormone therapy in the California Teachers Study

Table 3 SNPs that are statistically significantly associated with EPT-associated mammographic density change after correcting for multiple testing ^*

SNP (major/minor allele)	Gene	Minor allele frequency	N (WW/WV/VV)	beta	SE	P	P _ACT ^¶
rs7489119 (C/A)	SLCO1B1	0.041	258/23/1	−4.22	1.25	0.0008	0.018
rs5933863 (G/A)	ARSC	0.15	200/79/5	1.87	0.75	0.013	0.025

*Based on linear regression model adjusting for age and BMI (kg/m²) at time of on-EPT mammogram, time interval and BMI change between the two mammograms, and mammographic density of on-EPT mammogram. Additive genetic model was used. ^¶Multiple testing corrected P value; P _ACT (P values adjusted for correlated tests) within each gene was calculated using the methods by Conneely and Boehnke [33]. EPT, estrogen and progestin combined therapy; SNP, single nucleotide polymorphisms; SE, standard error; BMI, body mass index.

ISSN: 1465-542X