Gene | ER status | Grade | Diagnosis <50 years | Diagnosis ≥50-70 years | ||||||
---|---|---|---|---|---|---|---|---|---|---|
% Carriers (CIMBA) | % BCAC | LR | (95% CI) | % Carriers (CIMBA) | % BCAC | LR | (95% CI) | |||
BRCA1 | ER negative | Grade 1 | 0.8 | 1.4 | 0.59 | (0.36-0.98) | 0.6 | 1.2 | 0.51 | (0.18-1.40) |
ER negative | Grade 2 | 9.8 | 6.7 | 1.36 | (1.18-1.58) | 13.3 | 6.1 | 2.34 | (1.88-2.91) | |
ER negative | Grade 3 | 67.1 | 20.8 | 3.16 | (2.96-3.37) | 54.5 | 12.8 | 4.13 | (3.70-4.62) | |
ER positive | Grade 1 | 1.0 | 13.7 | 0.08 | (0.05-0.12) | 2.3 | 20.6 | 0.11 | (0.07-0.18) | |
ER positive | Grade 2 | 7.4 | 36.1 | 0.21 | (0.18-0.24) | 14.6 | 43.6 | 0.34 | (0.28-0.42) | |
ER positive | Grade 3 | 13.9 | 21.2 | 0.64 | (0.57-0.72) | 14.7 | 15.8 | 0.90 | (0.73-1.10) | |
 |  | 100% | 100% |  |  | 100% | 100% |  |  | |
- | Grade 1 | 2.1 | 15.8 | 0.13 | (0.10-0.16) | 2.9 | 22.3 | 0.12 | (0.08-0.18) | |
Grade 2 | 18.1 | 42.8 | 0.38 | (0.34-0.42) | 28.7 | 49.1 | 0.57 | (0.50-0.65) | ||
Grade 3 | 79.8 | 41.4 | 1.67 | (1.62-1.78) | 68.4 | 28.6 | 2.20 | (2.01-2.71) | ||
 |  | 100% | 100% |  |  | 100% | 100% |  |  | |
ER negative | - | 77.5 | 28.8 | 2.60 | (2.47-2.73) | 69.4 | 19.9 | 3.31 | (3.03-3.61) | |
ER positive | 22.5 | 71.2 | 0.32 | (0.29-0.34) | 30.6 | 80.1 | 0.37 | (0.32-0.42) | ||
 |  | 100% | 100% |  |  | 100% | 100% |  |  | |
BRCA2 | ER negative | Grade 1 | 0.7 | 1.4 | 0.51 | (0.25-1.05) | 1 | 1.2 | 0.86 | (0.36-2.08) |
ER negative | Grade 2 | 3.4 | 6.7 | 0.49 | (0.36-0.68) | 5.2 | 6.1 | 0.89 | (0.60-1.32) | |
ER negative | Grade 3 | 14.6 | 20.8 | 0.69 | (0.59-0.80) | 20.8 | 12.8 | 1.54 | (1.27-1.88) | |
ER positive | Grade 1 | 4.9 | 13.7 | 0.37 | (0.28-0.48) | 6.6 | 20.6 | 0.32 | (0.22-0.45) | |
ER positive | Grade 2 | 37.8 | 36.1 | 1.07 | (0.97-1.17) | 37.5 | 43.6 | 0.89 | (0.77-1.02) | |
ER positive | Grade 3 | 38.7 | 21.2 | 1.77 | (1.60-1.95) | 28.9 | 15.8 | 1.76 | (1.49-2.08) | |
 |  | 100% | 100% |  |  | 100% | 100% |  |  | |
- | Grade 1 | 5.7 | 15.8 | 0.33 | (0.26-0.41) | 8.6 | 22.3 | 0.35 | (0.27-0.46) | |
Grade 2 | 41.8 | 42.8 | 0.88 | (0.80-0.95) | 42.0 | 49.1 | 0.81 | (0.72-0.92) | ||
Grade 3 | 52.5 | 41.4 | 1.08 | (1.00-1.17) | 49.4 | 28.6 | 1.52 | (1.35-1.71) | ||
 |  | 100% | 100% |  |  | 100% | 100% |  |  | |
 | ER negative | - | 19.2 | 28.8 | 0.66 | (0.59-0.74) | 25.1 | 19.9 | 1.18 | (1.01-1.38) |
ER positive | 80.8 | 71.2 | 1.15 | (1.08-1.22) | 74.9 | 80.1 | 0.90 | (0.82-0.98) | ||
 |  | 100% | 100% |  |  | 100% | 100% |  |  |