MiR-183/-96/-182 cluster is up-regulated in most breast cancers and increases cell proliferation and migration

Breast Cancer Research

Table 1 Role of miR-183/-96/-182 in cancer based on recent publications within the last five years

miRNA	Oncogene/tumor suppressor	Cancer type	Function	Target genes	Reference
miR-96	Oncogene	Hepatocellular carcinoma	Increases proliferation and colony formation	FOXO1, FOXO3a	[2]
miR-96	Oncogene	Prostate cancer	Inhibits zinc uptake	ZIP1, ZIP3, ZIP7, ZIP9, ZnT1, ZnT7	[3]
miR-182
miR-183
miR-96	Oncogene	Medullo-blastoma	Inhibits apoptosis, destroys DNA repair, promotes cell migration	See reference	[4]
miR-182
miR-183
miR-96	Oncogene	Breast cancer	Induces proliferation	FOXO3a	[5]
miR-96	Oncogene	Breast cancer	Increases cell number	FOXO1	[6]
miR-182	Oncogene	Breast cancer	Increases cell number	FOXO1	[6]
miR-182	Oncogene	Glioma	Promotes glioma cell aggression	CYLD	[7]
miR-182	Oncogene	Melanoma	Promotes cell migration and survival	FOXO3	[8]
miR-183	Oncogene	Synovial sarcoma	Promotes tumor cell migration	EGR1	[9]
miR-183	Oncogene	Synovial sarcoma	Promotes tumor cell migration	PTEN	[9]
miR-183	Oncogene	Hepatocellular carcinoma	Iinhibits TGF-beta1-induced apoptosis	PDCD4	[10]
miR-96	Tumor suppressor	Pancreatic cancer	Decreases cell invasion, migration and tumor growth	KRAS	[11]
miR-183	Tumor suppressor	Breast cancer	Inhibits migration	Ezrin	[12]
miR-183	Tumor suppressor	Osteosarcoma	Inhibits migration and invasion	Ezrin	[13]
miR-182	Tumor suppressor	Lung cancer	Inhibits cancer cell proliferation	RGS17	[14]

ISSN: 1465-542X