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Figure 4 | Breast Cancer Research

Figure 4

From: MiR-183/-96/-182 cluster is up-regulated in most breast cancers and increases cell proliferation and migration

Figure 4

Up-regulation of the miR-183/-96/-182 cluster increased cell proliferation and migration. (A) The 3-(4, 5-dimethyl-2-thiazolyl)-2, 5-diphenyl-2H-tetrazolium bromide (MTT) assays showed that miR-183/-96/-182 cluster overexpression cell lines proliferated more rapidly than the vector control and non-infected cells. Error bars represent SD (n = 4). (B) Micrographs (left) and quantification (right) of crystal violet-stained cell colonies in miR-183/-96/-182 cluster overexpression MCF-7 cell lines and the vector control cells. Error bars represent SD (n = 4). (C) Cell wound-healing assays demonstrated that the migration abilities of overexpression cell lines were elevated: left panel, representative micrographs; right panel, quantification graph; upper panel, MCF-7 cells; lower panel, T47D cells. Error bars represent SD (n = 4). Scale bars: 100 μM.

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