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Table 1 Sox2 interacts with the promoters of stem cell and/or cancer-associated genes in RR cells

From: Profiling gene promoter occupancy of Sox2 in two phenotypically distinct breast cancer cell subsets using chromatin immunoprecipitation and genome-wide promoter microarrays

NCBI gene symbol

Description

Final peak score

PLXNA2

Plexin A2

3.19

FZD4

Frizzled homolog 4 (Drosophila)

3.16

MUC15

Mucin 15, cell surface associated

3.04

PLAU

Plasminogen activator, urokinase

2.89

ELF5*

E74-like factor 5 (ets domain transcription factor)

2.88

VCAM1

Vascular cell adhesion molecule 1

2.68

DACH2

Dachshund homolog 2 (Drosophila)

2.55

GPR49*

Leucine-rich repeat-containing G protein-coupled receptor 5

2.55

FYB

FYN binding protein

2.43

COL4A5

Collagen, type IV, alpha 5

2.40

MYH9

Myosin, heavy chain 9, non-muscle

2.39

PROM1 (CD133)*

Prominin 1

2.20

ESR2

Estrogen receptor 2 (ER beta)

2.19

PLAG1

Pleiomorphic adenoma gene 1

2.19

BMI1*

BMI1 polycomb ring finger oncogene

2.17

  1. List of RR ChIP-chip putative Sox2 target genes. Top-ranked 15 stem cell and/or cancer-associated genes of interest with >2.0 peak score derived from the MCF7 reporter responsive cells and their final adjusted microarray peak scores are summarized. The asterisks denote established stem cell markers.