Figure 3

Density distributions of age at onset of adrenarche, thelarche, pubarche and menarche by body mass index (BMI) z -score quartiles among all girls, aged 5 to 16 years. The hazard ratios and 95% CI for each pubertal milestone by BMI z-score quartile were: (A) adrenarche: Q1 = 1.0, Q2 = 1.0 (0.8, 1.2), Q3 = 1.0 (0.8, 1.1), Q4 = 1.1 (1.0, 1.2); P-trend = 0.30; (B) thelarche: Q1 = 1.0, Q2 = 1.1 (0.9, 1.5), Q3 = 1.3 (1.1, 1.6), Q4 = 1.3 (1.1, 1.5); P-trend <0.001; (C) pubarche: Q1 = 1.0, Q2 = 1.1 (0.8, 1.5), Q3 = 1.0 (0.9, 1.3), Q4 = 1.0 (0.9, 1.2); P-trend = 0.98; (D) menarche: Q1 = 1.0, Q2 = 1.2 (0.8, 1.8), Q3 = 1.1 (0.9, 1.5), Q4 = 1.2 (1.0, 1.4); P-trend = 0.50.