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Table 3 Quantification of 17q25.3 gain in BRCA1 -mutated and non-mutated TNBC by FISH

From: Identification by array comparative genomic hybridization of a new amplicon on chromosome 17q highly recurrent in BRCA1 mutated triple negative breast cancer

BRCA1   aCGH FISH: mean number of 17qter copies Mann-Whitney test FISH: % cells with ratio >3 Mann-Whitney test
Gain in 17q25.3 Median (IQR) Median (IQR)
Number + aCGH aCGH P -value aCGH aCGH P -value
Gain in 17q25.3 No gain in 17q25.3 Gain in 17q25.3 No gain in 17q25.3
All 44 26 18 3.6 (2.9 to 4.2) 2.1 (1.7 to 2.6) 0.0001 20.6 (11.5 to 35.4) 0 (0 to 3.8) 0.0001
Mutated 23 20 3 3.5 (2.7 to 4.2) 1.8 (1.8 to 2.7) 0.0199 20.6 (9.9 to 34.2) 0 (0 to 10.6) 0.0253
Non-mutated 21 6 15 3.6 (2.9 to 4.6) 2.1 (1.7 to 2.6) 0.0009 24.0 (14.1 to 33.9) 0 (0 to 3.5) 0.0007
  1. TNBC, triple-negative breast cancer; aCGH, array comparative genomic hybridization.