Identification by array comparative genomic hybridization of a new amplicon on chromosome 17q highly recurrent in BRCA1 mutated triple negative breast cancer

Table 3 Quantification of 17q25.3 gain in BRCA1 -mutated and non-mutated TNBC by FISH

BRCA1		aCGH		FISH: mean number of 17qter copies		Mann-Whitney test	FISH: % cells with ratio >3		Mann-Whitney test
		Gain in 17q25.3		Median (IQR)		Mann-Whitney test	Median (IQR)		Mann-Whitney test
	Number	+	−	aCGH	aCGH	P -value	aCGH	aCGH	P -value
	Number	+	−	Gain in 17q25.3	No gain in 17q25.3	P -value	Gain in 17q25.3	No gain in 17q25.3	P -value
All	44	26	18	3.6 (2.9 to 4.2)	2.1 (1.7 to 2.6)	0.0001	20.6 (11.5 to 35.4)	0 (0 to 3.8)	0.0001
Mutated	23	20	3	3.5 (2.7 to 4.2)	1.8 (1.8 to 2.7)	0.0199	20.6 (9.9 to 34.2)	0 (0 to 10.6)	0.0253
Non-mutated	21	6	15	3.6 (2.9 to 4.6)	2.1 (1.7 to 2.6)	0.0009	24.0 (14.1 to 33.9)	0 (0 to 3.5)	0.0007

TNBC, triple-negative breast cancer; aCGH, array comparative genomic hybridization.

ISSN: 1465-542X