Chromosomal aberrations along chromosome 17 in BRCA1 -mutated and non-mutated triple-negative breast cancer (TNBC). (A) Frequency of the chromosomal aberrations along chromosome 17 in BRCA1-mutated and non-mutated TNBC. Frequency of gains (red) and losses (green) on chromosome 17 are plotted according to their genome location for 23 BRCA1-mutated and 21 non-mutated TNBC. The most recurrent and significant aberration on chromosome 17 in BRCA1-mutated TNBC is surrounded by a blue frame in the q25.3 region. (B) Frequency of the 17q25.3 gain in BRCA1-mutated and non-mutated TNBC. The genome of 23 BRCA1-mutated and 21 non-mutated TNBC was analyzed by array comparative genomic hybridization (CGH). The presence of a chromosomal gain in the 17q25.3 region was determined for each tumor on the basis of the individual array CGH aberration profile analysis. Compared to the non-mutated TNBC, the gain in 17q25.3 was more frequent in BRCA1-mutated TNBC (P = 0.0002, two-tailed Fisher’s exact).