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Table 1 Details of GATA3 target genes tested in this work

From: Shift in GATA3 functions, and GATA3 mutations, control progression and clinical presentation in breast cancer

Gene Abbreviation Function Reference
B-cell CLL/lymphoma 2 BCL2 Anti-apoptotic [37]
Dachshund1 DACH1 • Anti-apoptotic [38]-[40],[42],[43]
• Inhibitor of estrogen signaling
• Cell cycle progression
• Inhibitor of breast cancer stem cells
• Inhibitor of tumor growth and metastasis
Thrombospondin, type I domain containing 4 THSD4 May promote matrix assembly [41]
Solute carrier organic anion transporter family, member 5A1 SLCO5A1 Nutrients (possibly hormones) uptake [44]
Growth regulation by estrogen in breast cancer 1 GREB1 Estrogen induced breast cancer cells growth/ proliferation [45]
Brain-enriched guanylate kinase-associated homolog BEGAIN Chromosome segregation [46]
Centrosomal protein 70 kDa CEP70 • Mitotic spindle assembly [47],[48]
• Angiogenesis
Rho-associated, coiled-coil containing protein kinase ROCK1 Serine/threonine kinase [49]-[52]
• Focal adhesion
• Cancer invasion/ metastasis
• Angiogenesis
• Apoptotic membrane blebbing
SUMO1/sentrin specific peptidase 5 SENP5 SUMO specific protease [53],[54]
• Cell division
• Proliferation
Kinesin family member 16B KIF16B Endosome transport and receptor recycling and degradation [55],[56]
• FGF/EGF signal transduction
Potassium channel tetramerisation domain containing 2 KCTD2 Ion transport [57]
• Upregulated in liver metastasis
ATP-dependent DNA helicase homolog HFM1 • Putative DNA helicase [58]
• Susceptibility to soft-tissue sarcoma
• Extensive tumor aneuploidy
Bone morphogenetic protein 2 BMP2 • TGF-β receptor antagonist [59]-[61]
• Cancer invasion/migration
• Cancer proliferation
• Tumor angiogenesis
• Hormone independence
v-erb-a erythroblastic leukemia viral oncogene homolog 4 ERBB4 (HER4) • EGF receptor [62],[63]
• Mammary gland differentiation
• Apoptosis
• Cell cycle and proliferation arrest in breast cancer