Table 1 Details of GATA3 target genes tested in this work

B-cell CLL/lymphoma 2

BCL2

Anti-apoptotic

[37]

Dachshund1

DACH1

• Anti-apoptotic

[38]-[40],[42],[43]

• Inhibitor of estrogen signaling

• Cell cycle progression

• Inhibitor of breast cancer stem cells

• Inhibitor of tumor growth and metastasis

Thrombospondin, type I domain containing 4

THSD4

May promote matrix assembly

[41]

Solute carrier organic anion transporter family, member 5A1

SLCO5A1

Nutrients (possibly hormones) uptake

[44]

Growth regulation by estrogen in breast cancer 1

GREB1

Estrogen induced breast cancer cells growth/ proliferation

[45]

Brain-enriched guanylate kinase-associated homolog

BEGAIN

Chromosome segregation

[46]

Centrosomal protein 70 kDa

CEP70

• Mitotic spindle assembly

[47],[48]

• Angiogenesis

Rho-associated, coiled-coil containing protein kinase

ROCK1

Serine/threonine kinase

[49]-[52]

• Focal adhesion

• Cancer invasion/ metastasis

• Angiogenesis

• Apoptotic membrane blebbing

SUMO1/sentrin specific peptidase 5

SENP5

SUMO specific protease

[53],[54]

• Cell division

• Proliferation

Kinesin family member 16B

KIF16B

Endosome transport and receptor recycling and degradation

[55],[56]

• FGF/EGF signal transduction

Potassium channel tetramerisation domain containing 2

KCTD2

Ion transport

[57]

• Upregulated in liver metastasis

ATP-dependent DNA helicase homolog

HFM1

• Putative DNA helicase

[58]

• Susceptibility to soft-tissue sarcoma

• Extensive tumor aneuploidy

Bone morphogenetic protein 2

BMP2

• TGF-β receptor antagonist

[59]-[61]

• Cancer invasion/migration

• Cancer proliferation

• Tumor angiogenesis

• Hormone independence

v-erb-a erythroblastic leukemia viral oncogene homolog 4

ERBB4 (HER4)

• EGF receptor

[62],[63]

• Mammary gland differentiation

• Apoptosis

• Cell cycle and proliferation arrest in breast cancer