Table 2 Categorization of single-nucleotide variants in 77 breast cancer tumors using dGene: 37 dGene entries present in at least 2 out of 77 samples, organized by class and patients affected

CASR

Calcium-sensing receptor

G protein-coupled receptor

3

GPR112

G protein-coupled receptor 112

G protein-coupled receptor

3

AGTR2

Angiotensin II receptor, type 2

G protein-coupled receptor

2

MC5R

Melanocortin 5 receptor

G protein-coupled receptor

2

OR2L2

Olfactory receptor, family 2, subfamily L, member 2

G protein-coupled receptor

2

OR51B5

Olfactory receptor, family 51, subfamily B, member 5

G protein-coupled receptor

2

PIK3CA

Phosphoinositide-3-kinase, catalytic, alpha polypeptide

PI3K

37

BIRC6

Baculoviral IAP repeat containing 6

Proteinase inhibitor

4

CPAMD8

C3 and PZP-like, α-2-macroglobulin domain containing 8

Proteinase inhibitor

3

COL28A1

Collagen, type XXVIII, alpha 1

Proteinase inhibitor

2

COL6A3

Collagen, type VI, alpha 3

Proteinase inhibitor

2

AGBL1

ATP/GTP binding protein-like 1

Protease

2

CPVL

Carboxypeptidase, vitellogenic-like

Protease

2

PCSK5

Proprotein convertase subtilisin/kexin type 5

Protease

2

RELN

Reelin

Protease

2

SENP7

SUMO1/sentrin specific peptidase 7

Protease

2

USP9X

Ubiquitin specific peptidase 9, X-linked

Protease

2

PTPRF

Protein tyrosine phosphatase, receptor type, F

Phosphatase

2

PTPRU

Protein tyrosine phosphatase, receptor type, U

Phosphatase

2

SSH3

Slingshot homolog 3 (Drosophila)

Phosohatase

2

MAP3K1

Mitogen-activated protein kinase kinase kinase 1

Serine theonine kinase

9

TTN

Titin

Serine theonine kinase

6

ATR

Ataxia telangiectasia and Rad3 related

Serine theonine kinase

5

OBSCN

Obscurin

Serine theonine kinase

3

SMG1

Smg-1 homolog

Serine theonine kinase

3

ALPK2

Alpha-kinase 2

Serine theonine kinase

2

BRAF

V-raf murine sarcoma viral oncogene homolog B1

Serine theonine kinase

2

DCLK3

Doublecortin-like kinase 3

Serine theonine kinase

2

LRRK2

Leucine-rich repeat kinase 2

Serine theonine kinase

2

MAP2K4

Mitogen-activated protein kinase kinase 4

Serine theonine kinase

2

TAF1L

TATA box binding protein (TBP)-associated factor

Serine theonine kinase

2

TBK1

TANK-binding kinase 1

Serine theonine kinase

2

ULK4

Unc-51-like kinase 4

Serine theonine kinase

2

INSRR

Insulin receptor-related receptor

Tyrosine kinase

3

KIT

C-kit

Tyrosine kinase

2

PDGFRA

Platelet-derived growth factor receptor

Tyrosine kinase

2

TEX14

Testis expressed 14

Tyrosine kinase

2