TY - JOUR AU - Siclari, Valerie A. AU - Mohammad, Khalid S. AU - Tompkins, Douglas R. AU - Davis, Holly AU - McKenna, C. Ryan AU - Peng, Xianghong AU - Wessner, Lisa L. AU - Niewolna, Maria AU - Guise, Theresa A. AU - Suvannasankha, Attaya AU - Chirgwin, John M. PY - 2014 DA - 2014/12/02 TI - Tumor-expressed adrenomedullin accelerates breast cancer bone metastasis JO - Breast Cancer Research SP - 458 VL - 16 IS - 6 AB - Adrenomedullin (AM) is secreted by breast cancer cells and increased by hypoxia. It is a multifunctional peptide that stimulates angiogenesis and proliferation. The peptide is also a potent paracrine stimulator of osteoblasts and bone formation, suggesting a role in skeletal metastases—a major site of treatment-refractory tumor growth in patients with advanced disease. SN - 1465-542X UR - https://doi.org/10.1186/s13058-014-0458-y DO - 10.1186/s13058-014-0458-y ID - Siclari2014 ER -