Skip to main content

Table 5 Testing data set results a

From: Pathologic response prediction to neoadjuvant chemotherapy utilizing pretreatment near-infrared imaging parameters and tumor pathologic criteria

Tumor pathologic variables

Receptors (core biopsy)

Pretreatment hemoglobin parameters

Sensitivity (%)/specificity (%)

PPV (%)/NPV (%)

AUC (%) (95% CI)

IDC/ILC, NS, MC

  

51.8/68.1

57.9/63.3

80.0 (51.11; 99.29)

IDC/ILC, NS, MC

TN, HER2, ER

 

56.8/88.9

84.8/70.9

84.0 (57.16; 99.03)

  

tHb

63.2/82.1

75.0/72.8

87.3 (62.13; 99.82)

  

oxyHb

60.8/81.9

73.6/71.4

84.0 (56.01; 100.0)

  

deoxyHb

52.2/89.6

80.4/69.1

72.2 (36.55; 97.67)

  

tHb, oxyHb

64.4/82.1

75.2/73.4

85.0 (57.61; 99.82)

  

tHb, deoxyHb

60.7/80.6

73.3/70.9

79.5 (56.32; 97.82)

IDC/ILC, NS, MC

TN, HER2, ER

tHb

78.7/93.6

89.5/85.9

92.4 (79.42; 99.80)

IDC/ILC, NS, MC

TN, HER2, ER

oxyHb

76.9/85.2

82.6/83.3

90.6 (74.36; 99.35)

IDC/ILC, NS, MC

TN, HER2, ER

deoxyHb

60.1/85.0

78.4/71.8

85.0 (58.78; 98.95)

IDC/ILC, NS, MC

TN, HER2, ER

tHb, oxyHb

73.2/84.9

81.8/81.7

88.6 (72.21; 97.51)

IDC/ILC, NS, MC

TN, HER2, ER

tHb, deoxyHb

71.5/84.3

79.5/79.1

85.0 (63.09; 99.53)

  1. aCI, confidence interval; deoxyHb, Deoxygenated hemoglobin; ER, Estrogen receptor; HER2, Human epidermal growth factor receptor 2; IDC, Invasive ductal carcinoma; IDC/ILC, Invasive mammary carcinoma with mixed ductal and lobular features; ILC, Invasive lobular carcinoma; MC, Mitotic count; NS, Nottingham score; oxyHb, Oxygenated hemoglobin; NPV, Negative predictive value; PPV, Positive predictive value; tHb, Total hemoglobin; TN, Triple-negative.