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Figure 2 | Breast Cancer Research

Figure 2

From: Functional variants at the 21q22.3 locus involved in breast cancer progression identified by screening of genome-wide estrogen response elements

Figure 2

Estrogen response element–associated single-nucleotide polymorphisms related to breast cancer incidence and progression. Genomic sites (A) and adjusted odds ratios (aORs), hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) (B) of the estrogen response element (ERE)–associated single-nucleotide polymorphisms (SNPs) found to be significantly associated with breast cancer incidence (left panel), overall survival (OS; center panel) or disease-free survival (DFS; right panel). Known genes adjacent to these SNPs are shown in gray in (A). aORs were estimated by logistic regression analyses, and the HRs were estimated by applying the Cox proportional hazards model. In total, 779 patients (106 deaths and 126 cases with breast cancer recurrence during follow-up) and 870 controls were included in these analyses.

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