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Figure 1 | Breast Cancer Research

Figure 1

From: Functional variants at the 21q22.3 locus involved in breast cancer progression identified by screening of genome-wide estrogen response elements

Figure 1

Identification and functional examination of genome-wide estrogen response element–associated single-nucleotide polymorphisms associated with breast cancer progression. (A) Flow diagram showing the sequential steps in the present study. (B) Selection of single-nucleotide polymorphisms (SNPs) to be genotyped. SNPs located within regions that bind estrogen receptor α (ERα) in vivo were selected, and then they were examined for whether they were located within the regions 10 kb 3' or 10 kb 5' of known estrogen (estradiol (E2))-responsive genes. As a result, after excluding those that could not be genotyped by using the iPLEX platform, 46 estrogen response element (ERE)–associated SNPs were genotyped. ChIP, Chromatin immunoprecipitation; DFS, Disease-free survival; OS, Overall survival.

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Breast Cancer Research

ISSN: 1465-542X

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