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Table 4 Numbers reclassified (absolute risk of developing breast cancer within the next 10 years 3%, 3 to 5%, 5 to 8%, 8 +%) for the Tyrer-Cuzick (TC) risk score modified using percent dense area compared to the Tyrer-Cuzick risk score modified using the density residual

From: Mammographic breast density refines Tyrer-Cuzick estimates of breast cancer risk in high-risk women: findings from the placebo arm of the International Breast Cancer Intervention Study I

TC + unadjusted density/TC + density residual

<3%

3-5%

5-8%

8%+

Total

Control

     

<3%

4 (100%)

0 (0%)

0 (0%)

0 (0%)

4 (1%)

3-5%

47 (89%)

6 (11%)

0 (0%)

0 (0%)

53 (11%)

5-8%

19 (13%)

105 (70%)

25 (17%)

0 (0%)

149 (31%)

8 +%

0 (0%)

29 (10%)

128 (47%)

117 (43%)

274 (57%)

Total

70 (15%)

140 (29%)

153 (32%)

117 (24%)

480 (100%)

Case

     

<3%

0 (0%)

0 (0%)

0 (0%)

0 (0%)

0 (0%)

3-5%

6 (55%)

5 (45%)

0 (0%)

0 (0%)

11 (15%)

5-8%

1 (6%)

15 (83%)

2 (11%)

0 (0%)

18 (25%)

8 +%

0 (0%)

4 (9%)

11 (26%)

28 (65%)

43 (60%)

Total

7 (10%)

24 (33%)

13 (18%)

28 (39%)

72 (100%)