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Table 2 Odds ratios (OR) and area under the curve (AUC) from the logistic regression models including absolute Tyrer-Cuzick (TC) risk score, unadjusted percent dense area and density residual as independent variables

From: Mammographic breast density refines Tyrer-Cuzick estimates of breast cancer risk in high-risk women: findings from the placebo arm of the International Breast Cancer Intervention Study I

Model Odds ratio(95% CI) AUC LR-CHI2 Δ χ2(Pvalue)a
Absolute TC risk score 1.18 (10.99-1.39) 0.51 3.5 0.06
Unadjusted percent dense area 1.83 (1.14-2.94) 0.59 6.5 0.01
Density residual 1.90 (1.31-2.77) 0.62 11.7 0.001
Absolute TC risk 1.12 (0.94-1.33)   3.5 0.06
Density residual 1.82 (1.25-2.67) 0.62 9.9 0.002
  1. Odds ratio is for the difference between the 75th and 25th percentiles of the Tyrer-Cuzick (TC) 10-year absolute risk, unadjusted percent dense area and the density residual; athis is the change in χ2 when the variable is added to the model.