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Table 1 Characteristics of Carolina Breast Cancer Study breast cancer cases or tumors evaluated or not evaluated for DNA methylation profile

From: DNA methylation profiling in the Carolina Breast Cancer Study defines cancer subclasses differing in clinicopathologic characteristics and survival

Characteristic   Cases evaluated for methylation Cases not evaluated Pvalue
(n =517) (n =163)
N (%) N (%)
Age Mean ± SD, years 49.7 ± 11.9 52.2 ± 11.9  
  <50 years 318 (62) 84 (52) 0.02
  50+ years 199 (38) 78 (48)  
Race       
  White/Othera 301 (58) 106 (65) 0.12
  African-American 216 (42) 57 (35)  
Menopausal status       
  Premenopausal 275 (53) 76 (47) 0.14
  Postmenopausal 242 (47) 87 (53)  
Stageb       
  I 178 (37) 68 (45) 0.37
  II 245 (51) 67 (44)  
  III 45 (9) 12 (8)  
  IV 13 (3) 4 (3)  
Primary tumor size       
  ≤2 cm 250 (50) 87 (57) 0.28
  >2-5 cm 205 (41) 52 (34)  
  >5 cm 42 (9) 13 (9)  
Lymph node status       
  Negative 291 (58) 101 (66) 0.11
  Positive 207 (42) 53 (34)  
Hormone receptor expression       
  ER+/PR+ 250 (50) 62 (42) 0.38
  ER+/PR- 48 (10) 17 (12)  
  ER-/PR+ 39 (8) 15 (10)  
  ER-/PR- 163 (33) 53 (36)  
Combined tumor gradec       
  I 126 (25) 47 (29) 0.48
  II 156 (30) 49 (30)  
  II 228 (45) 65 (40)  
Histologic type       
  Ductald 388 (75) 122 (75) 0.23
  Ductal variantse 13 (3) 9 (5)  
  Poorly differentiatedf 22 (4) 3 (2)  
  Lobularg 46 (9) 13 (8)  
  Mixed lobular/Ductal 48 (9) 16 (10)  
IHC intrinsic subtypeh       
  Luminal A 212 (51) 42 (51) 0.76
  Luminal B 65 (16) 12 (15)  
  Basal-like 86 (21) 14 (17)  
  HER2+/HR- 26 (6) 7 (8)  
  Unclassified 24 (6) 7 (8)  
p53 mutation status       
  Positive 218 (42) 47 (34) 0.08
  Negative 297 (58) 91 (66)  
  1. aThe white/other cases evaluated included 291 Caucasians, 3 American Indians, 6 Asians, and 1 other. bAccording to the American Joint Committee on Cancer breast tumor staging guidelines. cNottingham grade based on mitotic index, histologic grade, and nuclear grade. dDuctal not otherwise specified (n = 372), medullary (n = 3), neuroendocrine (n =2), apocrine (n = 2), and other mixed (n = 9). eDuctal variants include mucinous (n =8), papillary (n = 1), and cribriform (n = 4). fPoorly differentiated include metaplastic carcinoma (n = 6), anaplastic carcinoma (n =3), and undifferentiated high grade carcinoma (n = 13). gLobular, classic, and/or variant (n = 46). hIntrinsic subtype was determined by estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) status determined by medical records or immunohistochemistry (IHC), and IHC staining for CK5, CK6, and epidermal growth factor receptor. HR, hormone receptor; SD, standard deviation.