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Table 1 Identification of 32 genes associated with poor response to aromatase inhibitor therapy

From: Identification of chemokine receptors as potential modulators of endocrine resistance in oestrogen receptor–positive breast cancers

Gene Name In vitro Clinical
Fold change P -value Correlation coefficient P -value
ACTR2 ARP2 actin-related 2 homolog (yeast) 1.82 2.74E-05 -0.378 9.68E-04
AP1B1 Adaptor-related protein complex 1, β1 subunit 1.67 6.25E-04 -0.398 4.96E-04
ARID3A AT rich interactive domain 3A (BRIGHT-like) 1.60 1.36E-04 -0.352 2.25E-03
CCM2 Cerebral cavernous malformation 2 1.94 5.07E-05 -0.36 1.72E-03
CXCR4 Chemokine (C-X-C motif) receptor 4 1.51 5.05E-04 -0.302 9.26E-03
DTX2 Deltex homolog 2 (Drosophila) 2.24 8.19E-04 -0.338 3.41E-03
EML4 Echinoderm microtubule–associated protein–like 4 2.50 1.60E-06 -0.336 3.59E-03
FAM38A Family with sequence similarity 38, member A 3.59 5.02E-05 -0.338 3.42E-03
FBXL10 Lysine (K)-specific demethylase 2B 3.12 8.80E-06 -0.3 9.70E-03
IFNAR2 Interferon (α, β and ω) receptor 2 1.50 2.36E-04 -0.313 6.79E-03
IFNGR1 Interferon γ receptor 1 1.85 1.02E-04 -0.356 1.99E-03
IGF2R Insulin-like growth factor 2 receptor 2.93 1.20E-06 -0.319 5.84E-03
KIAA0513 KIAA0513 4.21 2.42E-04 -0.379 9.43E-04
LILRB1 Leukocyte immunoglobulin-like receptor, subfamily B, member 1 1.61 1.77E-04 -0.389 6.80E-04
LILRB3 Leukocyte immunoglobulin-like receptor, subfamily B, member 3 2.06 2.50E-06 -0.366 1.42E-03
MAP3K7 Mitogen-activated protein kinase 7 1.97 7.90E-06 -0.334 3.84E-03
MFHAS1 Malignant fibrous histiocytoma-amplified sequence 1 2.11 1.79E-05 -0.299 9.76E-03
MGAT1 Mannosyl glycoprotein acetylglucosaminyltransferase 1.70 1.33E-04 -0.313 6.78E-03
MICAL1 Microtubule-associated monooxygenase, calponin/LIM domain 2.43 7.00E-07 -0.385 7.65E-04
NPC2 Niemann-Pick disease, type C2 2.37 3.09E-05 -0.421 2.12E-04
PHACTR2 Phosphatase and actin regulator 2 3.20 1.22E-05 -0.35 2.39E-03
PLEKHF1 Pleckstrin homology domain containing, family F, member 1 2.13 3.51E-05 -0.369 1.31E-03
RGS19 Regular of G-protein signaling 19 1.52 7.14E-04 -0.474 2.54E-05
SLC15A4 Solute carrier family 15, member 4 1.54 9.13E-05 -0.307 7.91E-03
ST8SIA4 ST8 α-N-acetyl-neuraminide α-2,8-sialyltransferase 4 2.45 2.74E-04 -0.32 5.64E-03
TNRC6B Trinucleotide repeat containing 6B 2.13 1.90E-04 -0.3 9.74E-03
TTYH3 Tweety homolog 3 (Drosophila) 2.72 4.65E-04 -0.408 3.42E-04
WDFY1 WD repeat and FYVE domain containing 1 2.27 3.00E-06 -0.349 2.40E-03
XPO6 Exportin 6 1.80 4.64E-04 -0.312 6.99E-03
YWHAH Tyrosine/tryptophan monooxygenase activation protein 1.44 4.83E-04 -0.365 1.50E-03
ZBED4 Zinc finger, BED-type containing 4 1.59 5.93E-05 -0.337 3.48E-03
ZCCHC11 Zinc finger, CCHC domain containing 11 1.36 4.75E-04 -0.433 1.36E-04