Table 1 Identification of 32 genes associated with poor response to aromatase inhibitor therapy

ACTR2

ARP2 actin-related 2 homolog (yeast)

1.82

2.74E-05

-0.378

9.68E-04

AP1B1

Adaptor-related protein complex 1, β₁ subunit

1.67

6.25E-04

-0.398

4.96E-04

ARID3A

AT rich interactive domain 3A (BRIGHT-like)

1.60

1.36E-04

-0.352

2.25E-03

CCM2

Cerebral cavernous malformation 2

1.94

5.07E-05

-0.36

1.72E-03

CXCR4

Chemokine (C-X-C motif) receptor 4

1.51

5.05E-04

-0.302

9.26E-03

DTX2

Deltex homolog 2 (Drosophila)

2.24

8.19E-04

-0.338

3.41E-03

EML4

Echinoderm microtubule–associated protein–like 4

2.50

1.60E-06

-0.336

3.59E-03

FAM38A

Family with sequence similarity 38, member A

3.59

5.02E-05

-0.338

3.42E-03

FBXL10

Lysine (K)-specific demethylase 2B

3.12

8.80E-06

-0.3

9.70E-03

IFNAR2

Interferon (α, β and ω) receptor 2

1.50

2.36E-04

-0.313

6.79E-03

IFNGR1

Interferon γ receptor 1

1.85

1.02E-04

-0.356

1.99E-03

IGF2R

Insulin-like growth factor 2 receptor

2.93

1.20E-06

-0.319

5.84E-03

KIAA0513

KIAA0513

4.21

2.42E-04

-0.379

9.43E-04

LILRB1

Leukocyte immunoglobulin-like receptor, subfamily B, member 1

1.61

1.77E-04

-0.389

6.80E-04

LILRB3

Leukocyte immunoglobulin-like receptor, subfamily B, member 3

2.06

2.50E-06

-0.366

1.42E-03

MAP3K7

Mitogen-activated protein kinase 7

1.97

7.90E-06

-0.334

3.84E-03

MFHAS1

Malignant fibrous histiocytoma-amplified sequence 1

2.11

1.79E-05

-0.299

9.76E-03

MGAT1

Mannosyl glycoprotein acetylglucosaminyltransferase

1.70

1.33E-04

-0.313

6.78E-03

MICAL1

Microtubule-associated monooxygenase, calponin/LIM domain

2.43

7.00E-07

-0.385

7.65E-04

NPC2

Niemann-Pick disease, type C2

2.37

3.09E-05

-0.421

2.12E-04

PHACTR2

Phosphatase and actin regulator 2

3.20

1.22E-05

-0.35

2.39E-03

PLEKHF1

Pleckstrin homology domain containing, family F, member 1

2.13

3.51E-05

-0.369

1.31E-03

RGS19

Regular of G-protein signaling 19

1.52

7.14E-04

-0.474

2.54E-05

SLC15A4

Solute carrier family 15, member 4

1.54

9.13E-05

-0.307

7.91E-03

ST8SIA4

ST8 α-N-acetyl-neuraminide α-2,8-sialyltransferase 4

2.45

2.74E-04

-0.32

5.64E-03

TNRC6B

Trinucleotide repeat containing 6B

2.13

1.90E-04

-0.3

9.74E-03

TTYH3

Tweety homolog 3 (Drosophila)

2.72

4.65E-04

-0.408

3.42E-04

WDFY1

WD repeat and FYVE domain containing 1

2.27

3.00E-06

-0.349

2.40E-03

XPO6

Exportin 6

1.80

4.64E-04

-0.312

6.99E-03

YWHAH

Tyrosine/tryptophan monooxygenase activation protein

1.44

4.83E-04

-0.365

1.50E-03

ZBED4

Zinc finger, BED-type containing 4

1.59

5.93E-05

-0.337

3.48E-03

ZCCHC11

Zinc finger, CCHC domain containing 11

1.36

4.75E-04

-0.433

1.36E-04