p130Cas/BCAR1 and Nedd9 structural features and main interacting proteins. Schematic representation of Cas protein main domains: an amino-terminal SH3 domain followed by a proline-rich region (PRR), a substrate domain (SD), a serine rich region (SRR), and a carboxy-terminal domain (CT). The main proteins whose interaction has been demonstrated for both p130Cas and Nedd9 are indicated in black, the interactors specific for p130Cas are in red and those specific for Nedd9 are in green. Noteworthy, p125FAK binds to the SH3 domain while the Src family kinases bind to the CT domain. The substrate domain with the multiple YxxP motifs represents the site where Src family kinases extensively phosphorylate Cas proteins.