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Figure 8 | Breast Cancer Research

Figure 8

From: Profiling the tyrosine phosphoproteome of different mouse mammary tumour models reveals distinct, model-specific signalling networks and conserved oncogenic pathways

Figure 8

Protein expression, tyrosine phosphorylation and gene copy number for Met and Cav1. (A) and (B) Immunoblot quantitation of total protein expression compared with relative tyrosine phosphorylation of the corresponding protein obtained by mass spectrometry. Data are presented as in Figure 2. Colour key and histogram apply to (A) and (B). The heat maps indicate the intensity of phosphorylation on the following specific sites: MET (pY1354) and Cav1 (pY14). (C) Array comparative genomic hybridisation profile of mouse chromosome 6 in the different p53 tumours, showing the 1,556-kb stretch where the genes for Cav1 and Met are located. (D) Lower-resolution view of the amplified region. The intensity of blue or red indicates gene copy number. Heat map in (C) also applies to (D).

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Breast Cancer Research

ISSN: 1465-542X

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