| Enriched GO functions and pathways | Enriched TFs |
---|---|---|
Cluster 1 | • Cell-cycle G2-M | FOXM1, GATA |
• Stem cell development | ||
• Increased adenoma | ||
• TGF-β, PDGF and HIF2α signaling pathways | ||
Cluster 2 | • Genes regulated by ESR1 | ERα, FOXM1, CREB, ATF3 |
• Genes upregulated in the luminal B subtype of breast cancer | ||
Cluster 3 | Subgroup A | Â |
• Genes associated with acquired endocrine therapy resistance in breast tumors expressing ESR1 | ERα, FOXM1, AP-1 | |
• Focal adhesion |  | |
• Neoplasm |  | |
Subgroup B | FOXM1, ERα, AP-1 | |
• Cell substrate adherens junction |  | |
• Cytoskeleton regulation and rearrangement | ||
• Neoplasm | ||
• Response to hypoxia | ||
Subgroup C | FOXM1, GATA, ERα | |
• Epithelial cell development |  | |
• p53 pathway | ||
• HIF1α transcription factor network | ||
Cluster 4 | • Translation | FOXM1, GATA, Elk, AP-1, JunD |
• Mammary gland hyperplasia | ||
• Abnormal apoptosis | ||
• Abnormal mitotic index |