Skip to main content

Table 1 Enriched Gene Ontology functions, pathways and transcription factor motifs in the seqMINER-identified FOXM1 binding site clusters a

From: The forkhead transcription factor FOXM1 promotes endocrine resistance and invasiveness in estrogen receptor-positive breast cancer by expansion of stem-like cancer cells

 

Enriched GO functions and pathways

Enriched TFs

Cluster 1

• Cell-cycle G2-M

FOXM1, GATA

• Stem cell development

• Increased adenoma

• TGF-β, PDGF and HIF2α signaling pathways

Cluster 2

• Genes regulated by ESR1

ERα, FOXM1, CREB, ATF3

• Genes upregulated in the luminal B subtype of breast cancer

Cluster 3

Subgroup A

 

• Genes associated with acquired endocrine therapy resistance in breast tumors expressing ESR1

ERα, FOXM1, AP-1

• Focal adhesion

 

• Neoplasm

 

Subgroup B

FOXM1, ERα, AP-1

• Cell substrate adherens junction

 

• Cytoskeleton regulation and rearrangement

• Neoplasm

• Response to hypoxia

Subgroup C

FOXM1, GATA, ERα

• Epithelial cell development

 

• p53 pathway

• HIF1α transcription factor network

Cluster 4

• Translation

FOXM1, GATA, Elk, AP-1, JunD

• Mammary gland hyperplasia

• Abnormal apoptosis

• Abnormal mitotic index

  1. aAP-1, Activator protein 1; ATF3, Activating transcription factor 3; CREB, cAMP response element-binding-protein; ERα, Estrogen receptor α; GO, Gene Ontology; HIF, Hypoxia-inducible factor; PDGF, Platelet-derived growth factor; TFs, Transcription factors; TGF-β, Transforming growth factor β.