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Figure 1 | Breast Cancer Research

Figure 1

From: The forkhead transcription factor FOXM1 promotes endocrine resistance and invasiveness in estrogen receptor-positive breast cancer by expansion of stem-like cancer cells

Figure 1

Clinical data indicating that high expression of FOXM1 in estrogen receptor-positive breast tumors is correlated with high expression of 14-3-3ζ and a poor clinical outcome. (A) Among the FOX family members, FOXM1 expression level most highly correlated with 14-3-3ζ expression level in primary breast tumors. Microarray gene expression data are derived from our findings in 251 estrogen receptor-positive (ER+) breast tumors [38]. Box plots are shown for 27 FOX family members with error bars spanning minimum to maximum values, and heat maps (below) show strong agreement between expression of FOXM1 and 14-3-3ζ/YWHAZ in breast tumors. Factor analysis (top left) reveals that FOXM1 and 14-3-3ζ are linearly correlated. (B) Tumors positive for 14-3-3ζ and FOXM1 by IUC show the earliest time to recurrence. P = 0.041 based on two-way analysis of variance with Dunnett's multiple-comparisons test for multigroup comparison. (C) Kaplan-Meier stratification of overall survival of tamoxifen-treated patients [38],[41] based on FOXM1 mRNA expression. (D) Kaplan-Meier analysis of disease-free survival of ER+ patients according to IHC scores for negative/low FOXM1 expression (blue curve) versus high FOXM1 expression (green curve) (P = 0.003) analyzed using the logrank test.

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