Table 2 Estimates of hazard ratio with multivariate analysis in ER + breast cancers, with different CD8+ iTIL status

Age

1.06

0.536

1.03

0.803

1.14

0.449

≥50 vs. <50

(0.88 - 1.27)

(0.82 - 1.29)

(0.82 - 1.59)

Grade

1.67

<0.001

1.67

<0.001

1.71

0.001

3 vs. (1 and 2)

(1.41 - 1.99)

(1.35 - 2.05)

(1.24 - 2.36)

Tumor size

1.76

<0.001

1.75

<0.001

1.66

0.002

>2 cm vs. ≤2 cm

(1.48 - 2.10)

(1.41 - 2.16)

(1.21 - 2.27)

Nodal status

1.98

<0.001

2.18

<0.001

1.51

0.017

Positive vs. negative

(1.63 - 2.40)

(1.72 - 2.77)

(1.08 - 2.13)

LVI

1.30

0.007

1.33

0.020

1.24

0.209

Positive vs. negative

(1.07 - 1.57)

(1.05 - 1.68)

(0.89 - 1.74)

FOXP3+ iTIL

1.14

0.138

1.30

0.032

1.00

0.978

≥2 vs. <2

(0.96 - 1.37)

(1.02 - 1.66)

(0.74 - 1.34)