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Table 2 Estimates of hazard ratio with multivariate analysis in ER + breast cancers, with different CD8+ iTIL status

From: Prognostic significance of FOXP3+ tumor-infiltrating lymphocytes in breast cancer depends on estrogen receptor and human epidermal growth factor receptor-2 expression status and concurrent cytotoxic T-cell infiltration

Variable ER + (n = 2166) ER+/CD8+ iTIL = 0 (n = 1474) ER+/CD8+ iTIL ≥1 (n = 624)
  HR (95% CI) P HR (95% CI) P HR (95% CI) P
Age 1.06 0.536 1.03 0.803 1.14 0.449
≥50 vs. <50 (0.88 - 1.27)   (0.82 - 1.29)   (0.82 - 1.59)  
Grade 1.67 <0.001 1.67 <0.001 1.71 0.001
3 vs. (1 and 2) (1.41 - 1.99)   (1.35 - 2.05)   (1.24 - 2.36)  
Tumor size 1.76 <0.001 1.75 <0.001 1.66 0.002
>2 cm vs. ≤2 cm (1.48 - 2.10)   (1.41 - 2.16)   (1.21 - 2.27)  
Nodal status 1.98 <0.001 2.18 <0.001 1.51 0.017
Positive vs. negative (1.63 - 2.40)   (1.72 - 2.77)   (1.08 - 2.13)  
LVI 1.30 0.007 1.33 0.020 1.24 0.209
Positive vs. negative (1.07 - 1.57)   (1.05 - 1.68)   (0.89 - 1.74)  
FOXP3+ iTIL 1.14 0.138 1.30 0.032 1.00 0.978
≥2 vs. <2 (0.96 - 1.37)   (1.02 - 1.66)   (0.74 - 1.34)  
  1. CI, confidence interval; ER, estrogen receptor; HR, hazard ratio; iTIL, intratumoral tumor-infiltrating lymphocyte; LVI, lymphovascular invasion.