Characteristics | Number of patients | FOXP3+ iTILs (≥2) | |
---|---|---|---|
 | (%) | Prevalence % | Pvalue |
Age at diagnosis (year) | Â | Â | <0.001 |
<40 | 294 (7.4) | 41.6 (106/255) | Â |
40-49 | 844 (21.1) | 38.5 (264/685) | Â |
50-65 | 1,425 (35.7) | 29.5 (350/1186) | Â |
>65 | 1,429 (35.8) | 27.0 (311/1150) | Â |
Grade | Â | Â | <0.001 |
1 (well differentiated) | 209 (5.2) | 16.3 (25/153) | Â |
2 (moderately well or partially differentiated) | 1,563 (39.2) | 23.7 (305/1288) | Â |
3 (poorly differentiated) | 2,040 (51.1) | 38.9 (661/1699) | Â |
Unknown | 180 (4.5) | Â | Â |
Tumor size (cm) | Â | Â | 0.201 |
≤2 | 2,078 (52.1) | 30.2 (512/1697) |  |
>2-5 | 1,667 (41.8) | 33.1 (461/1394) | Â |
> 5 | 221 (5.5) | 29.8 (50/168) | Â |
Unknown | 26 (0.6) | Â | Â |
Nodal status | Â | Â | 0.003 |
Negative | 2,265 (56.7) | 29.4 (545/1856) | Â |
Positive | 1,719 (43.1) | 34.2 (484/1414) | Â |
Unknown | 8 (0.2) | Â | Â |
Lymphovascular invasion (LVI) | Â | Â | 0.218 |
Negative | 2,106 (52.8) | 30.3 (522/1720) | Â |
Positive | 1,710 (42.8) | 32.4 (461/1423) | Â |
Unknown | 176 (4.4) | Â | Â |
AJCC stage | Â | Â | 0.003 |
I | 1,393 (34.9) | 27.7 (314/1132) | Â |
II | 2,255 (56.5) | 33.7 (630/1872) | Â |
III | 317 (7.9) | 32.2 (82/255) | Â |
Unknown/missing | 27 (0.7) | Â | Â |
Adjuvant systemic therapy (AST)* | Â | Â | <0.001 |
No AST | 1,676 (42.0) | 29.0 (402/1386) | Â |
Tamoxifen only | 1,276 (32.0) | 27.7 (287/1037) | Â |
Chemotherapy only | 727 (18.2) | 40.6 (245/603) | Â |
Tamoxifen + chemotherapy | 297 (7.4) | 38.8 (92/237) | Â |
Other | 16 (0.4) | 35.7 (5/14) | Â |
ER | Â | Â | <0.001 |
Negative | 1,200 (30.1) | 42.7 (388/909) | Â |
Positive (≥1% nuclei stained) | 2,761 (69.1) | 27.2 (641/2354) |  |
Uninterpretable/missing | 31 (0.8) | Â | Â |
HER2 | Â | Â | <0.001 |
Negative | 3,316 (83.1) | 29.9 (830/2779) | Â |
Positive | 498 (12.5) | 42.4 (184/434) | Â |
Uninterpretable/missing | 178 (4.4) | Â | Â |
Subtype | Â | Â | <0.001 |
Luminal A | 1,518 (38.0) | 20.8 (275/1325) | Â |
Luminal B | 829 (20.8) | 36.8 (276/749) | Â |
Luminal/HER2 | 224 (5.6) | 39.5 (79/200) | Â |
Luminal not further assigned | 244 (6.1) | 19.5 (29/149) | Â |
HER2+/ER– | 250 (6.3) | 45.9 (102/222) |  |
TNP | 630 (15.8) | 42.2 (226/535) | Â |
Core basal | 330 (8.3) | 54.0 (163/302) | Â |
5NP | 162 (4.1) | 36.5 (50/137) | Â |
TNP not assignable | 138 (3.4) | 39.5 (34/86) | Â |
Unassignable | 297 (7.4) | 21.5 (23/107) | Â |
CD8+ iTIL | Â | Â | <0.001 |
0 | 2,299 (57.6) | 19.6 (410/2094) | Â |
≥1 | 1,104 (27.6) | 56.6 (591/1044) |  |
Uninterpretable/missing | 589 (14.8) | Â | Â |
Total | 3,992 (100) | 31.5 (1031/3277) | Â |