|
Age at diagnosis (year)
| | |
<0.001
|
|
<40
|
294 (7.4)
|
41.6 (106/255)
| |
|
40-49
|
844 (21.1)
|
38.5 (264/685)
| |
|
50-65
|
1,425 (35.7)
|
29.5 (350/1186)
| |
|
>65
|
1,429 (35.8)
|
27.0 (311/1150)
| |
|
Grade
| | |
<0.001
|
|
1 (well differentiated)
|
209 (5.2)
|
16.3 (25/153)
| |
|
2 (moderately well or partially differentiated)
|
1,563 (39.2)
|
23.7 (305/1288)
| |
|
3 (poorly differentiated)
|
2,040 (51.1)
|
38.9 (661/1699)
| |
|
Unknown
|
180 (4.5)
| | |
|
Tumor size (cm)
| | |
0.201
|
|
≤2
|
2,078 (52.1)
|
30.2 (512/1697)
| |
|
>2-5
|
1,667 (41.8)
|
33.1 (461/1394)
| |
|
> 5
|
221 (5.5)
|
29.8 (50/168)
| |
|
Unknown
|
26 (0.6)
| | |
|
Nodal status
| | |
0.003
|
|
Negative
|
2,265 (56.7)
|
29.4 (545/1856)
| |
|
Positive
|
1,719 (43.1)
|
34.2 (484/1414)
| |
|
Unknown
|
8 (0.2)
| | |
|
Lymphovascular invasion (LVI)
| | |
0.218
|
|
Negative
|
2,106 (52.8)
|
30.3 (522/1720)
| |
|
Positive
|
1,710 (42.8)
|
32.4 (461/1423)
| |
|
Unknown
|
176 (4.4)
| | |
|
AJCC stage
| | |
0.003
|
|
I
|
1,393 (34.9)
|
27.7 (314/1132)
| |
|
II
|
2,255 (56.5)
|
33.7 (630/1872)
| |
|
III
|
317 (7.9)
|
32.2 (82/255)
| |
|
Unknown/missing
|
27 (0.7)
| | |
|
Adjuvant systemic therapy (AST)*
| | |
<0.001
|
|
No AST
|
1,676 (42.0)
|
29.0 (402/1386)
| |
|
Tamoxifen only
|
1,276 (32.0)
|
27.7 (287/1037)
| |
|
Chemotherapy only
|
727 (18.2)
|
40.6 (245/603)
| |
|
Tamoxifen + chemotherapy
|
297 (7.4)
|
38.8 (92/237)
| |
|
Other
|
16 (0.4)
|
35.7 (5/14)
| |
|
ER
| | |
<0.001
|
|
Negative
|
1,200 (30.1)
|
42.7 (388/909)
| |
|
Positive (≥1% nuclei stained)
|
2,761 (69.1)
|
27.2 (641/2354)
| |
|
Uninterpretable/missing
|
31 (0.8)
| | |
|
HER2
| | |
<0.001
|
|
Negative
|
3,316 (83.1)
|
29.9 (830/2779)
| |
|
Positive
|
498 (12.5)
|
42.4 (184/434)
| |
|
Uninterpretable/missing
|
178 (4.4)
| | |
|
Subtype
| | |
<0.001
|
|
Luminal A
|
1,518 (38.0)
|
20.8 (275/1325)
| |
|
Luminal B
|
829 (20.8)
|
36.8 (276/749)
| |
|
Luminal/HER2
|
224 (5.6)
|
39.5 (79/200)
| |
|
Luminal not further assigned
|
244 (6.1)
|
19.5 (29/149)
| |
|
HER2+/ER–
|
250 (6.3)
|
45.9 (102/222)
| |
|
TNP
|
630 (15.8)
|
42.2 (226/535)
| |
|
Core basal
|
330 (8.3)
|
54.0 (163/302)
| |
|
5NP
|
162 (4.1)
|
36.5 (50/137)
| |
|
TNP not assignable
|
138 (3.4)
|
39.5 (34/86)
| |
|
Unassignable
|
297 (7.4)
|
21.5 (23/107)
| |
|
CD8+ iTIL
| | |
<0.001
|
|
0
|
2,299 (57.6)
|
19.6 (410/2094)
| |
|
≥1
|
1,104 (27.6)
|
56.6 (591/1044)
| |
|
Uninterpretable/missing
|
589 (14.8)
| | |
|
Total
|
3,992 (100)
|
31.5 (1031/3277)
| |
