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Table 2 Clinicopathological characteristics according to CIP2A expression a

From: Tamoxifen induces apoptosis through cancerous inhibitor of protein phosphatase 2A–dependent phospho-Akt inactivation in estrogen receptor–negative human breast cancer cells

Characteristic

Moderate to low CIP2A expression,

High CIP2A expression,

P-value

n = 103 (%)

n = 20 (%)

Median age (IQR)

55 (49.0 to 67.0)

49 (40.75 to 55.50)

0.401

Advanced clinical stage (stages III and IV)

23 (22.3)

11 (55.0)

0.011

Microvascular invasion

23 (22.3)

9 (45.0)

0.001

HER2-positiveb

47 (45.6)

6 (30.0)

0.337

High p-Akt expression

49 (47.6)

12 (60.0)

0.338

5-year PFSc

76.7%

55%

0.034

  1. aCIP2A, Cancerous inhibitor of protein phosphatase 2A; HER2, Human epidermal growth factor receptor 2; PFS, Progression-free survival. bHER2-positive was defined as an immunohistochemical staining score of 3+ or 2+ with gene amplification shown by fluorescence in situ hybridization. cMedian follow-up period 50.5 months (IQR = 34.1 to 86.8).
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Breast Cancer Research

ISSN: 1465-542X

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