Table 3 Relationship between methylation and phenotypic features of digital carcinoma in situ

High nuclear grade

64.9% HG, 34.9% non-HG P = 0.013

P = 1.000

P = 1.000

67.6% HG, 41.9% non-HG P = 0.026

P = 0.073

P = 0.178

P = 1.000

P = 0.106

P = 0.275

P = 1.000

P = 0.116

Architectural pattern

P = 0.620

P = 1.000

P = 0.907

P = 0.256

P = 0.596

P = 0.519

P = 0.399

P = 0.365

P = 0.254

P = 0.311

P = 0.402

Comedo necrosis

P = 0.175

P = 1.000

P = 0.503

P = 0.500

P = 0.159

P = 0.498

P = 0.652

P = 1.000

100% CN, 82.6% non-CN P = 0.018

P = 0.253

P = 0.824

ERα

41.5% ERα+, 75% ERα- P = 0.017

P = 1.000

P = 0.481

47.2% ERα+, 80% ERα- P = 0.017

P = 0.246

P = 0.794

P = 0.111

27.8% ERα+, 75% ERα-P <0.001

P = 0.336

P = 0.604

P = 0.794

PgR

P = 0.236

P = 1.000

P = 1.000

37.2% PgR+, 83.3% PgR- P <0.001

P = 0.473

P = 1.000

P = 0.230

23.3% PgR+, 64.5% PgR- P = 0.001

P = 1.000

P = 1.000

P = 0.346

HER2

P = 0.607

P = 1.000

P = 1.000

81.0% HER2, 46.2% non-HER2 P = 0.009

P = 0.711

P = 0.302

P = 0.305

59.1% HER2, 32.7% non-HER2 P = 0.042

P = 0.173

P = 0.446

P = 0.607

Intrinsic subtype

P = 0.184

P = 1.000

P = 0.252

Basal 50%, HER2 81.0%, Luminal 39.5%, Negative 85.7%

P = 0.006

P = 0.136

P = 0.08

P = 0.368

Basal 100%, HER2 59.1%, Luminal 23.3%, Negative 71.4% P = 0.003

P = 0.113

P = 0.597

P = 0.111