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Table 3 Relationship between methylation and phenotypic features of digital carcinoma in situ

From: Methylation profiling of ductal carcinoma in situand its relationship to histopathological features

  Methylated gene
APC BRCA1 CDH1 CDH13 FOXC1 GSTP1 MAL RARB RASSF1A TWIST1 WIF1
High nuclear grade 64.9% HG, 34.9% non-HG P = 0.013 P = 1.000 P = 1.000 67.6% HG, 41.9% non-HG P = 0.026 P = 0.073 P = 0.178 P = 1.000 P = 0.106 P = 0.275 P = 1.000 P = 0.116
Architectural pattern P = 0.620 P = 1.000 P = 0.907 P = 0.256 P = 0.596 P = 0.519 P = 0.399 P = 0.365 P = 0.254 P = 0.311 P = 0.402
Comedo necrosis P = 0.175 P = 1.000 P = 0.503 P = 0.500 P = 0.159 P = 0.498 P = 0.652 P = 1.000 100% CN, 82.6% non-CN P = 0.018 P = 0.253 P = 0.824
ERα 41.5% ERα+, 75% ERα- P = 0.017 P = 1.000 P = 0.481 47.2% ERα+, 80% ERα- P = 0.017 P = 0.246 P = 0.794 P = 0.111 27.8% ERα+, 75% ERα-P <0.001 P = 0.336 P = 0.604 P = 0.794
PgR P = 0.236 P = 1.000 P = 1.000 37.2% PgR+, 83.3% PgR- P <0.001 P = 0.473 P = 1.000 P = 0.230 23.3% PgR+, 64.5% PgR- P = 0.001 P = 1.000 P = 1.000 P = 0.346
HER2 P = 0.607 P = 1.000 P = 1.000 81.0% HER2, 46.2% non-HER2 P = 0.009 P = 0.711 P = 0.302 P = 0.305 59.1% HER2, 32.7% non-HER2 P = 0.042 P = 0.173 P = 0.446 P = 0.607
Intrinsic subtype P = 0.184 P = 1.000 P = 0.252 Basal 50%, HER2 81.0%, Luminal 39.5%, Negative 85.7%
P = 0.006
P = 0.136 P = 0.08 P = 0.368 Basal 100%, HER2 59.1%, Luminal 23.3%, Negative 71.4% P = 0.003 P = 0.113 P = 0.597 P = 0.111
  1. HG, high nuclear grade, CN, comedo necrosis. Detailed results of all analyses are tabulated in Additional file 6.