From: Methylation profiling of ductal carcinoma in situand its relationship to histopathological features
 | Methylated gene | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
APC | BRCA1 | CDH1 | CDH13 | FOXC1 | GSTP1 | MAL | RARB | RASSF1A | TWIST1 | WIF1 | |
High nuclear grade | 64.9% HG, 34.9% non-HG P = 0.013 | P = 1.000 | P = 1.000 | 67.6% HG, 41.9% non-HG P = 0.026 | P = 0.073 | P = 0.178 | P = 1.000 | P = 0.106 | P = 0.275 | P = 1.000 | P = 0.116 |
Architectural pattern | P = 0.620 | P = 1.000 | P = 0.907 | P = 0.256 | P = 0.596 | P = 0.519 | P = 0.399 | P = 0.365 | P = 0.254 | P = 0.311 | P = 0.402 |
Comedo necrosis | P = 0.175 | P = 1.000 | P = 0.503 | P = 0.500 | P = 0.159 | P = 0.498 | P = 0.652 | P = 1.000 | 100% CN, 82.6% non-CN P = 0.018 | P = 0.253 | P = 0.824 |
ERα | 41.5% ERα+, 75% ERα- P = 0.017 | P = 1.000 | P = 0.481 | 47.2% ERα+, 80% ERα- P = 0.017 | P = 0.246 | P = 0.794 | P = 0.111 | 27.8% ERα+, 75% ERα-P <0.001 | P = 0.336 | P = 0.604 | P = 0.794 |
PgR | P = 0.236 | P = 1.000 | P = 1.000 | 37.2% PgR+, 83.3% PgR- P <0.001 | P = 0.473 | P = 1.000 | P = 0.230 | 23.3% PgR+, 64.5% PgR- P = 0.001 | P = 1.000 | P = 1.000 | P = 0.346 |
HER2 | P = 0.607 | P = 1.000 | P = 1.000 | 81.0% HER2, 46.2% non-HER2 P = 0.009 | P = 0.711 | P = 0.302 | P = 0.305 | 59.1% HER2, 32.7% non-HER2 P = 0.042 | P = 0.173 | P = 0.446 | P = 0.607 |
Intrinsic subtype | P = 0.184 | P = 1.000 | P = 0.252 | Basal 50%, HER2 81.0%, Luminal 39.5%, Negative 85.7% P = 0.006 | P = 0.136 | P = 0.08 | P = 0.368 | Basal 100%, HER2 59.1%, Luminal 23.3%, Negative 71.4% P = 0.003 | P = 0.113 | P = 0.597 | P = 0.111 |