From: Methylation profiling of ductal carcinoma in situand its relationship to histopathological features
 | Negative for methylation | Positive for methylation | |||||||
---|---|---|---|---|---|---|---|---|---|
 | Frequencies (%) | ||||||||
Gene | Sample type | No methylation | Low heterogenous methylation | Low homogenous methylation | High heterogenous methylation | Moderate homogenous methylation | High homogenous methylation | Total positive for methylation | No data |
APC | Normal | 15/15 (100) | 0/15 (0) | 0/15 (0) | 0/15 (0) | 0/15 (0) | 0/15 (0) | 0/15 (0) | 3 |
 | Pure ductal carcinoma in situ (DCIS) | 29/70 (41.4) | 0/70 (0) | 4/70 (5.7) | 4/70 (5.7) | 27/70 (38.6) | 6/70 (8.6) | 37/70 (52.9) | 2 |
 | Mixed DCIS | 7/10 (70) | 1/10 (10) | 0/10 (0) | 0/10 (0) | 1/10 (10) | 1/10 (10) | 2/10 (20) | 0 |
BRCA1 | Normal | 17/17 (100) | 0/17 (0) | 0/17 (0) | 0/17 (0) | 0/17 (0) | 0/17 (0) | 0/17 (0) | 1 |
 | Pure DCIS | 70/70 (100) | 0/70 (0) | 0/70 (0) | 0/70 (0) | 0/70 (0) | 0/70 (0) | 0/70 (0) | 2 |
 | Mixed DCIS | 10/10 (100) | 0/10 (0) | 0/10 (0) | 0/10 (0) | 0/10 (0) | 0/10 (0) | 0/10 (0) | 0 |
CDH1 | Normal | 16/17 (94.1) | 0/17 (0) | 1/17 (5.9) | 0/17 (0) | 0/17 (0) | 0/17 (0) | 0/17 (0) | 1 |
 | Pure DCIS | 62/69 (89.9) | 0/69 (0) | 5/69 (7.2) | 2/69 (2.9) | 0/69 (0) | 0/69 (0) | 2/69 (2.9) | 3 |
 | Mixed DCIS | 9/10 (90) | 0/10 (0) | 1/10 (10) | 0/10 (0) | 0/10 (0) | 0/10 (0) | 0/10 (0) | 0 |
CDH13 | Normal | 16/18 (88.9) | 0/18 (0) | 1/18 (5.6) | 0/18 (0) | 1/18 (5.6) | 0/18 (0) | 1/18 (5.6) | 0 |
 | Pure DCIS | 30/70 (42.9) | 0/70 (0) | 0/70 (0) | 32/70 (45.7) | 6/70 (8.6) | 2/70 (2.9) | 40/70 (57.1) | 2 |
 | Mixed DCIS | 6/10 (60) | 1/10 (10) | 0/10 (0) | 2/10 (20) | 0/10 (0) | 1/10 (10) | 3/10 (30) | 0 |
FOXC1 | Normal | 16/17 (94.1) | 0/17 (0) | 1/17 (5.9) | 0/17 (0) | 0/17 (0) | 0/17 (0) | 0/17 (0) | 1 |
 | Pure DCIS | 59/70 (84.3) | 1/70 (1.4) | 3/70 (4.3) | 6/70 (8.6) | 1/70 (1.4) | 0/70 (0) | 7/70 (10) | 2 |
 | Mixed DCIS | 7/10 (70) | 1/10 (10) | 0/10 (0) | 1/10 (10) | 1/10 (10) | 0/10 (0) | 2/10 (20) | 0 |
GSTP1 | Normal | 15/16 (93.8) | 0/16 (0) | 1/16 (6.3) | 0/16 (0) | 0/16 (0) | 0/16 (0) | 0/16 (0) | 2 |
 | Pure DCIS | 30/70 (42.9) | 4/70 (5.7) | 1/70 (1.4) | 10/70 (14.3) | 7/70 (10) | 18/70 (25.7) | 35/70 (50) | 2 |
 | Mixed DCIS | 7/10 (70) | 0/10 (0) | 0/10 (0) | 1/10 (10) | 1/10 (10) | 1/10 (10) | 3/10 (30) | 0 |
MAL | Normal | 14/15 (93.3) | 0/15 (0) | 1/15 (6.7) | 0/15 (0) | 0/15 (0) | 0/15 (0) | 0/15 (0) | 3 |
 | Pure DCIS | 31/69 (44.9) | 5/69 (7.2) | 1/69 (1.4) | 32/69 (46.3) | 0/69 (0) | 0/69 (0) | 32/69 (46.3) | 3 |
 | Mixed DCIS | 3/10 (30) | 0/10 (0) | 0/10 (0) | 7/10 (70) | 0/10 (0) | 0/10 (0) | 7/10 (70) | 0 |
RARβ | Normal | 17/17 (100) | 0/17 (0) | 0/17 (0) | 0/17 (0) | 0/17 (0) | 0/17 (0) | 0/17 (0) | 1 |
 | Pure DCIS | 43/71 (60.6) | 0/71 (0) | 1/71 (1.4) | 1/71 (1.4) | 16/71 (22.5) | 10/71 (14.1) | 27/71 (38.0) | 1 |
 | Mixed DCIS | 7/10 (70) | 0/10 (0) | 0/10 (0) | 0/10 (0) | 0/10 (0) | 3/10 (30) | 3/10 (30) | 0 |
RASSF1A | Normal | 15/18 (83.3) | 1/18 (5.6) | 2/18 (11.1) | 0/18 (0) | 0/18 (0) | 0/18 (0) | 0/18 (0) | 0 |
 | Pure DCIS | 6/70 (8.6) | 0/70 (0) | 2/70 (2.9) | 0/70 (0) | 32/70 (45.7) | 30/70 (42.9) | 62/70 (88.6) | 2 |
 | Mixed DCIS | 0/10 (0) | 0/10 (0) | 0/10 (0) | 0/10 (0) | 4/10 (40) | 6/10 (60) | 10/10 (100) | 0 |
TWIST1 | Normal | 16/17 (94.1) | 0/17 (0) | 0/17 (0) | 1/17 (5.9) | 0/17 (0) | 0/17 (0) | 1/17 (5.9) | 1 |
 | Pure DCIS | 34/71 (47.9) | 4/71 (5.6) | 4/71 (5.6) | 26/71 (36.6) | 3/71 (4.2) | 0/71 (0) | 29/71 (41.4) | 1 |
 | Mixed DCIS | 6/10 (60) | 0/10 (0) | 0/10 (0) | 3/10 (30) | 0/10 (0) | 1/10 (10) | 4/10 (40) | 0 |
WIF1 | Normal | 13/18 (72.2) | 0/18 (0) | 0/18 (0) | 5/18 (27.8) | 0/18 (0) | 0/18 (0) | 5/18 (27.8) | 0 |
 | Pure DCIS | 31/70 (44.3) | 0/70 (0) | 5/70 (7.1) | 31/70 (44.3) | 3/70 (4.3) | 0/70 (0) | 34/70 (48.6) | 2 |
 | Mixed DCIS | 4/10 (40) | 0/10 (0) | 1/10 (10) | 3/10 (30) | 2/10 (20) | 0/10 (0) | 5/10 (50) | 0 |