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Table 2 Frequency and level of methylation of genes by sample type

From: Methylation profiling of ductal carcinoma in situand its relationship to histopathological features

  Negative for methylation Positive for methylation
  Frequencies (%)
Gene Sample type No methylation Low heterogenous methylation Low homogenous methylation High heterogenous methylation Moderate homogenous methylation High homogenous methylation Total positive for methylation No data
APC Normal 15/15 (100) 0/15 (0) 0/15 (0) 0/15 (0) 0/15 (0) 0/15 (0) 0/15 (0) 3
  Pure ductal carcinoma in situ (DCIS) 29/70 (41.4) 0/70 (0) 4/70 (5.7) 4/70 (5.7) 27/70 (38.6) 6/70 (8.6) 37/70 (52.9) 2
  Mixed DCIS 7/10 (70) 1/10 (10) 0/10 (0) 0/10 (0) 1/10 (10) 1/10 (10) 2/10 (20) 0
BRCA1 Normal 17/17 (100) 0/17 (0) 0/17 (0) 0/17 (0) 0/17 (0) 0/17 (0) 0/17 (0) 1
  Pure DCIS 70/70 (100) 0/70 (0) 0/70 (0) 0/70 (0) 0/70 (0) 0/70 (0) 0/70 (0) 2
  Mixed DCIS 10/10 (100) 0/10 (0) 0/10 (0) 0/10 (0) 0/10 (0) 0/10 (0) 0/10 (0) 0
CDH1 Normal 16/17 (94.1) 0/17 (0) 1/17 (5.9) 0/17 (0) 0/17 (0) 0/17 (0) 0/17 (0) 1
  Pure DCIS 62/69 (89.9) 0/69 (0) 5/69 (7.2) 2/69 (2.9) 0/69 (0) 0/69 (0) 2/69 (2.9) 3
  Mixed DCIS 9/10 (90) 0/10 (0) 1/10 (10) 0/10 (0) 0/10 (0) 0/10 (0) 0/10 (0) 0
CDH13 Normal 16/18 (88.9) 0/18 (0) 1/18 (5.6) 0/18 (0) 1/18 (5.6) 0/18 (0) 1/18 (5.6) 0
  Pure DCIS 30/70 (42.9) 0/70 (0) 0/70 (0) 32/70 (45.7) 6/70 (8.6) 2/70 (2.9) 40/70 (57.1) 2
  Mixed DCIS 6/10 (60) 1/10 (10) 0/10 (0) 2/10 (20) 0/10 (0) 1/10 (10) 3/10 (30) 0
FOXC1 Normal 16/17 (94.1) 0/17 (0) 1/17 (5.9) 0/17 (0) 0/17 (0) 0/17 (0) 0/17 (0) 1
  Pure DCIS 59/70 (84.3) 1/70 (1.4) 3/70 (4.3) 6/70 (8.6) 1/70 (1.4) 0/70 (0) 7/70 (10) 2
  Mixed DCIS 7/10 (70) 1/10 (10) 0/10 (0) 1/10 (10) 1/10 (10) 0/10 (0) 2/10 (20) 0
GSTP1 Normal 15/16 (93.8) 0/16 (0) 1/16 (6.3) 0/16 (0) 0/16 (0) 0/16 (0) 0/16 (0) 2
  Pure DCIS 30/70 (42.9) 4/70 (5.7) 1/70 (1.4) 10/70 (14.3) 7/70 (10) 18/70 (25.7) 35/70 (50) 2
  Mixed DCIS 7/10 (70) 0/10 (0) 0/10 (0) 1/10 (10) 1/10 (10) 1/10 (10) 3/10 (30) 0
MAL Normal 14/15 (93.3) 0/15 (0) 1/15 (6.7) 0/15 (0) 0/15 (0) 0/15 (0) 0/15 (0) 3
  Pure DCIS 31/69 (44.9) 5/69 (7.2) 1/69 (1.4) 32/69 (46.3) 0/69 (0) 0/69 (0) 32/69 (46.3) 3
  Mixed DCIS 3/10 (30) 0/10 (0) 0/10 (0) 7/10 (70) 0/10 (0) 0/10 (0) 7/10 (70) 0
RARβ Normal 17/17 (100) 0/17 (0) 0/17 (0) 0/17 (0) 0/17 (0) 0/17 (0) 0/17 (0) 1
  Pure DCIS 43/71 (60.6) 0/71 (0) 1/71 (1.4) 1/71 (1.4) 16/71 (22.5) 10/71 (14.1) 27/71 (38.0) 1
  Mixed DCIS 7/10 (70) 0/10 (0) 0/10 (0) 0/10 (0) 0/10 (0) 3/10 (30) 3/10 (30) 0
RASSF1A Normal 15/18 (83.3) 1/18 (5.6) 2/18 (11.1) 0/18 (0) 0/18 (0) 0/18 (0) 0/18 (0) 0
  Pure DCIS 6/70 (8.6) 0/70 (0) 2/70 (2.9) 0/70 (0) 32/70 (45.7) 30/70 (42.9) 62/70 (88.6) 2
  Mixed DCIS 0/10 (0) 0/10 (0) 0/10 (0) 0/10 (0) 4/10 (40) 6/10 (60) 10/10 (100) 0
TWIST1 Normal 16/17 (94.1) 0/17 (0) 0/17 (0) 1/17 (5.9) 0/17 (0) 0/17 (0) 1/17 (5.9) 1
  Pure DCIS 34/71 (47.9) 4/71 (5.6) 4/71 (5.6) 26/71 (36.6) 3/71 (4.2) 0/71 (0) 29/71 (41.4) 1
  Mixed DCIS 6/10 (60) 0/10 (0) 0/10 (0) 3/10 (30) 0/10 (0) 1/10 (10) 4/10 (40) 0
WIF1 Normal 13/18 (72.2) 0/18 (0) 0/18 (0) 5/18 (27.8) 0/18 (0) 0/18 (0) 5/18 (27.8) 0
  Pure DCIS 31/70 (44.3) 0/70 (0) 5/70 (7.1) 31/70 (44.3) 3/70 (4.3) 0/70 (0) 34/70 (48.6) 2
  Mixed DCIS 4/10 (40) 0/10 (0) 1/10 (10) 3/10 (30) 2/10 (20) 0/10 (0) 5/10 (50) 0