Evaluation of functional genetic variants at 6q25.1 and risk of breast cancer in a Chinese population

Wang, Yanru; He, Yisha; Qin, Zhenzhen; Jiang, Yue; Jin, Guangfu; Ma, Hongxia; Dai, Juncheng; Chen, Jiaping; Hu, Zhibin; Guan, Xiaoxiang; Shen, Hongbing

doi:10.1186/s13058-014-0422-x

Breast Cancer Research

Table 2 Stratified analysis of the associations between rs9383935, rs2046210, rs2228480 and rs3798758 with breast cancer risk

From: Evaluation of functional genetic variants at 6q25.1 and risk of breast cancer in a Chinese population

Characteristics	rs9383935		P-value^b	rs2046210		P-value^b	rs2228480		P-value^b	rs3798758		P-value^b
Characteristics	OR (95% CI)^a	P-value^a	P-value^b	OR (95% CI)^a	P-value^a	P-value^b	OR (95% CI)^a	P-value^a	P-value^b	OR (95% CI)^a	P-value^a	P-value^b
Age, yr
<51	1.43 (1.19 to 1.71)	0.0001	0.556	1.36 (1.15 to 1.62)	0.0005	0.599	0.82 (0.67 to 1.02)	0.071	0.798	1.31 (1.08 to 1.57)	0.005	0.138
≥51	1.32 (1.09 to 1.60)	0.0048		1.27 (1.06 to 1.53)	0.0114		0.86 (0.68 to 1.07)	0.180		1.06 (0.86 to 1.30)	0.613
Age at menarche, yr
<16	1.39 (1.15 to 1.68)	0.0006	0.914	1.31 (1.09 to 1.57)	0.0039	0.879	0.98 (0.79 to 1.22)	0.849	0.061	1.13 (0.93 to 1.38)	0.234	0.466
≥16	1.37 (1.14 to 1.65)	0.0007		1.34 (1.12 to 1.59)	0.0012		0.73 (0.59 to 0.91)	0.005		1.25 (1.03 to 1.52)	0.022
Age at first live birth, yr
<24	1.52 (1.18 to 1.95)	0.0011	0.368	1.39 (1.09 to 1.77)	0.0077	0.621	0.91 (0.68 to 1.21)	0.505	0.611	1.21 (0.93 to 1.58)	0.152	0.730
≥24	1.32 (1.13 to 1.56)	0.0007		1.29 (1.11 to 1.51)	0.0012		0.83 (0.69 to 1.00)	0.048		1.15 (0.97 to 1.36)	0.114
Menopausal status
Premenopausal	1.37 (1.14 to 1.65)	0.0010	0.876	1.30 (1.08 to 1.55)	0.0049	0.725	0.83 (0.66 to 1.04)	0.109	0.889	1.23 (1.01 to 1.49)	0.037	0.300
Postmenopausal^c	1.40 (1.15 to 1.70)	0.0008		1.36 (1.13 to 1.64)	0.0014		0.85 (0.68 to 1.06)	0.151		1.06 (0.86 to 1.30)	0.613
ER status
Positive	1.30 (1.10 to 1.53)	0.0018	0.324	1.24 (1.06 to 1.46)	0.0068	0.148	0.80 (0.65 to 0.97)	0.025	0.765	1.21 (1.02 to 1.48)	0.030	0.732
Negative	1.47 (1.23 to 1.75)	2.5 × 10^-5		1.48 (1.24 to 1.76)	1.05 × 10^-5		0.76 (0.61 to 0.95)	0.014		1.16 (0.96 to 1.40)	0.126
PR status
Positive	1.33 (1.13 to 1.57)	0.0005	0.618	1.31 (1.12 to 1.53)	0.0008	0.645	0.79 (0.65 to 0.96)	0.020	0.886	1.18 (0.99 to 1.41)	0.063	0.869
Negative	1.42 (1.19 to 1.70)	0.0001		1.38 (1.16 to 1.64)	0.0003		0.77 (0.62 to 0.97)	0.023		1.21 (1.00 to 1.46)	0.055

^aAdjusted for age, age at menarche and menopausal status where appropriate. ^bP-value for heterogeneity. ^cPostmenopausal status for natural menopause.

Back to article page

ISSN: 1465-542X

Contact us

Submission enquiries: journalsubmissions@springernature.com