Skip to main content

Table 2 Stratified analysis of the associations between rs9383935, rs2046210, rs2228480 and rs3798758 with breast cancer risk

From: Evaluation of functional genetic variants at 6q25.1 and risk of breast cancer in a Chinese population

Characteristics rs9383935 P-valueb rs2046210 P-valueb rs2228480 P-valueb rs3798758 P-valueb
OR (95% CI)a P-valuea OR (95% CI)a P-valuea OR (95% CI)a P-valuea OR (95% CI)a P-valuea
Age, yr             
<51 1.43 (1.19 to 1.71) 0.0001 0.556 1.36 (1.15 to 1.62) 0.0005 0.599 0.82 (0.67 to 1.02) 0.071 0.798 1.31 (1.08 to 1.57) 0.005 0.138
≥51 1.32 (1.09 to 1.60) 0.0048   1.27 (1.06 to 1.53) 0.0114   0.86 (0.68 to 1.07) 0.180   1.06 (0.86 to 1.30) 0.613  
Age at menarche, yr             
<16 1.39 (1.15 to 1.68) 0.0006 0.914 1.31 (1.09 to 1.57) 0.0039 0.879 0.98 (0.79 to 1.22) 0.849 0.061 1.13 (0.93 to 1.38) 0.234 0.466
≥16 1.37 (1.14 to 1.65) 0.0007   1.34 (1.12 to 1.59) 0.0012   0.73 (0.59 to 0.91) 0.005   1.25 (1.03 to 1.52) 0.022  
Age at first live birth, yr             
<24 1.52 (1.18 to 1.95) 0.0011 0.368 1.39 (1.09 to 1.77) 0.0077 0.621 0.91 (0.68 to 1.21) 0.505 0.611 1.21 (0.93 to 1.58) 0.152 0.730
≥24 1.32 (1.13 to 1.56) 0.0007   1.29 (1.11 to 1.51) 0.0012   0.83 (0.69 to 1.00) 0.048   1.15 (0.97 to 1.36) 0.114  
Menopausal status             
Premenopausal 1.37 (1.14 to 1.65) 0.0010 0.876 1.30 (1.08 to 1.55) 0.0049 0.725 0.83 (0.66 to 1.04) 0.109 0.889 1.23 (1.01 to 1.49) 0.037 0.300
Postmenopausalc 1.40 (1.15 to 1.70) 0.0008   1.36 (1.13 to 1.64) 0.0014   0.85 (0.68 to 1.06) 0.151   1.06 (0.86 to 1.30) 0.613  
ER status             
Positive 1.30 (1.10 to 1.53) 0.0018 0.324 1.24 (1.06 to 1.46) 0.0068 0.148 0.80 (0.65 to 0.97) 0.025 0.765 1.21 (1.02 to 1.48) 0.030 0.732
Negative 1.47 (1.23 to 1.75) 2.5 × 10-5   1.48 (1.24 to 1.76) 1.05 × 10-5   0.76 (0.61 to 0.95) 0.014   1.16 (0.96 to 1.40) 0.126  
PR status             
Positive 1.33 (1.13 to 1.57) 0.0005 0.618 1.31 (1.12 to 1.53) 0.0008 0.645 0.79 (0.65 to 0.96) 0.020 0.886 1.18 (0.99 to 1.41) 0.063 0.869
Negative 1.42 (1.19 to 1.70) 0.0001   1.38 (1.16 to 1.64) 0.0003   0.77 (0.62 to 0.97) 0.023   1.21 (1.00 to 1.46) 0.055  
  1. aAdjusted for age, age at menarche and menopausal status where appropriate. bP-value for heterogeneity. cPostmenopausal status for natural menopause.