Exemplary plasma DNA analyses from patients B49 and B60 and plasma DNA copy number patterns from a panel of patients with metastatic breast cancer. (a) Patient B60 demonstrated an enrichment of plasma DNA fragments at 160 bps whereas B49 had plasma DNA fragments at about 315 bps in addition. (b) Corresponding plasma-Seq profiles of B60 and B49. (c) Copy number patterns established from a panel of patients with metastatic breast cancer. Depicted are recurrent aberrations (upper panel gains, lower panel losses), the Y-axis represents relative abundance of respective aberrations of unbalanced copy number profiles. Data from patients with balanced copy number profiles were not included. These analyses revealed losses of 1p, 8p, 13q, and 16q, and gains of 1q, 8q, 16p, and 17q.