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Table 1 Characterization of pure luminobasal (pLB) and pure luminal (pLUM) cells

From: Modeling luminal breast cancer heterogeneity: combination therapy to suppress a hormone receptor-negative, cytokeratin 5-positive subpopulation in luminal disease

 

Immunohistochemistry

mRNA

Factors

pLB

pLUM

Fold pLB versus pLUM

CK5

+++

-

+ 7,336

Jag1

+

-

+ 809

Annexin A1

+++

+

+ 405

EGFR

++

-

+ 146

Slug (SNAI2)

+

-

+ 103

p63 (TP63)

++

-

+ 65

CD49f (Itga6)

+++

-

+ 23

p-Cadherin (CDH3)

++

-

+ 20

Notch-1

+

-

+ 8

CD44

++

-

+ 1.3

CK8/18

+

+++

- 3

FOXA1

-

++

- 5

GATA3

-

++

- 46

ER

-

++

- 70

Claudin-3

-

++

- 113

Muc1

-

++

- 118

PR

-

++

- 189

  1. CK5, cytokeratin 5; EGFR, epidermal growth factor receptor; ER, estrogen receptor; PR, progesterone receptor.