Figure 4

Specific metabolic/genetic associations. (A) The mean level of 2-hydroxyglutarate (2-HG) in 5 normal tissues, 16 estrogen receptor (ER) + and 9 ER- tumors. (B) The level of 2-HG in breast cancer cell lines (4 luminal type and 5 basal type cells). (C) Kynurenine is derived from tryptophan by indoleamine 2,3-dioxygenase (IDO) or tryptophan 2,3-dioxygenase (TDO) enzymatic activity. (D) The level of tryptophan and kynurenine in 5 normal tissues, 16 ER + and 9 ER- tumors. (E) The correlation between the level of kynurenine and IDO1 gene expression measured by RNAseq in 23 tumors analyzed by The Cancer Genome Atlas (TCGA). (F) The correlation between RNA expression of the mesenchymal/basal marker vimentin and IDO1 in TCGA breast cancers.