Figure 1

Breast cancers (n = 25) and normal breast tissues (n = 5) were grouped by unsupervised hierarchical clustering of metabolite levels and overlaid with intrinsic subtype and status of the somatic mutations of genetic drivers. Normalized metabolite levels were mean-centered, selected based on at least two-fold changes in two samples and arranged by hierarchical clustering. The estrogen receptor (ER) status, intrinsic subtypes, and identified somatic mutations in the indicated genes are shown for 23 tumors which were characterized by The Cancer Genome Atlas (TCGA).