Characteristics | Categories | N at risk | LE (%) | HR (95% CI)a | HR (95% CI)b |
---|---|---|---|---|---|
Breast cancer and treatment | Â | Â | Â | Â | Â |
Age at diagnosis (years) | 35-44 | 123 | 43 (35.0) | 1.00 | 1.00 |
45-49 | 128 | 43 (33.6) | 0.98 (0.64 - 1.50) | 0.98 (0.63 - 1.52) | |
50-54 | 175 | 46 (26.3) | 0.80 (0.52 - 1.21) | 0.79 (0.51 - 1.23) | |
55-59 | 128 | 35 (27.3) | 0.83 (0.53 - 1.30) | 0.78 (0.49 - 1.23) | |
60-64 | 112 | 23 (20.5) | 0.59 (0.35 - 0.97) | 0.61 (0.35 - 1.06) | |
Per unit of age | Â | Â | 0.98 (0.96 - 1.00) | 0.98 (0.96 - 1.00) | |
 |  |  | P trend = 0.03 | P trend = 0.04 | |
Disease stage | In situ | 155 | 15 (9.7) | 0.26 (0.15 - 0.45) | Â |
Localized | 346 | 105 (30.4) | 1.00 | Â | |
Regional | 165 | 70 (42.4) | 1.35 (0.99 - 1.85) | Â | |
Tumor size (mm) | <10 | 178 | 36 (20.2) | 1.00 | Â |
10-19 | 216 | 66 (30.6) | 1.54 (1.02 - 2.32) | Â | |
20+ | 208 | 76 (36.5) | 1.85 (1.23 - 2.77) | Â | |
Missing | 64 | 12 (18.8) | 0.80 (0.41 - 1.54) | Â | |
Per mm | Â | Â | 1.01 (1.00 - 1.02) | Â | |
 |  |  | P trend = 0.02 |  | |
Cancer location | Nipple, central portion, upper/lower inner quadrant | 143 | 44 (30.8) | 1.15 (0.80 - 1.66) | Â |
Upper/lower outer quadrant | 292 | 83 (28.4) | 1.00 | Â | |
Overlapping lesion | 147 | 44 (29.9) | 1.07 (0.74 - 1.55) | Â | |
Axillary tail, NOS | 84 | 19 (22.6) | 0.75 (0.46 - 1.24) | Â | |
Surgery type | Partial/less than total mastectomy/surgery, NOS | 442 | 108 (24.4) | 1.00 | 1.00 |
Total mastectomy/modified radical mastectomy | 224 | 82 (36.6) | 1.52 (1.13 - 2.04) | 1.37 (1.01 - 1.85) | |
Reconstructive surgery | No | 533 | 150 (28.1) | 1.00 | Â |
Yes | 105 | 33 (31.4) | 0.98 (0.67 - 1.45) | Â | |
Missing | 28 | 7 (25.0) | - | Â | |
Number of excised lymph nodes | 0 | 143 | 9 (6.3) | 0.13 (0.06 - 0.25) | 0.17 (0.08 - 0.33) |
1-9c | 162 | 32 (19.8) | 0.44 (0.30 - 0.64) | 0.46 (0.31 - 0.68) | |
10+ | 361 | 149 (41.3) | 1.00 | 1.00 | |
Per lymph node | Â | Â | 1.06 (1.04 - 1.08) | 1.05 (1.03 - 1.07) | |
 |  |  | P trend <0.001 | P trend < 0.001 | |
Radiation | No | 270 | 73 (27.0) | 1.00 | Â |
Yes | 396 | 117 (29.6) | 1.21 (0.90 - 1.63) | Â | |
Chemotherapy | No | 413 | 83 (20.1) | 1.00 | 1.00 |
Yes | 253 | 107 (42.3) | 2.28 (1.69 - 3.09) | 1.48 (1.09 - 2.02) | |
Tamoxifen | No | 382 | 96 (25.1) | 1.00 | Â |
Yes | 284 | 94 (33.1) | 1.58 (1.18 - 2.12) | Â | |
Sociodemographic factors | Â | Â | Â | Â | Â |
Race/ethnicity | Non-Hispanic white (NM, WW) | 371 | 88 (23.7) | 1.00 | 1.00 |
Black (LA) | 226 | 82 (36.3) | 1.62 (1.20 - 2.20) | 1.16 (0.83 - 1.61) | |
Hispanic white (NM) | 69 | 20 (29.0) | 1.19 (0.73 - 1.94) | 1.04 (0.63 - 1.70) | |
Marital status | Married | 445 | 123 (27.6) | 1.00 | Â |
Widowed | 34 | 10 (29.4) | 1.25 (0.64 - 2.43) | Â | |
Divorced/separated | 140 | 46 (32.9) | 1.20 (0.86 - 1.69) | Â | |
Never married | 47 | 11 (23.4) | 0.85 (0.45 - 1.58) | Â | |
Education | High school or less | 158 | 48 (30.4) | 1.00 | Â |
Some college | 249 | 75 (30.1) | 0.92 (0.63 - 1.33) | Â | |
College graduate | 120 | 39 (32.5) | 1.14 (0.73 - 1.77) | Â | |
Graduate studies | 139 | 28 (20.1) | 0.65 (0.40 - 1.07) | Â | |
Insurance | Yes | 618 | 180 (29.1) | 1.00 | Â |
No | 25 | 8 (32.0) | 1.04 (0.51 - 2.12) | Â | |
Missing | 23 | 2 (8.7) | - | Â | |
Health-related factors | Â | Â | Â | Â | Â |
Body mass index prior to diagnosis (kg/m2) | <25 | 306 | 70 (22.9) | 1.00 | 1.00 |
25-29.9 | 220 | 67 (30.5) | 1.40 (0.99 - 1.96) | 1.25 (0.88 - 1.76) | |
30+ | 140 | 53 (37.9) | 1.83 (1.27 - 2.63) | 1.59 (1.09 - 2.31) | |
Per unit of BMI | Â | Â | 1.04 (1.02 - 1.07) | 1.04 (1.01 - 1.06) | |
 |  |  | P trend < 0.001 | P trend = 0.01 | |
Menopausal statusd | Premenopausal | 259 | 82 (31.7) | 1.00 | Â |
Postmenopausal | 341 | 80 (23.5) | 0.81 (0.51 - 1.28) | Â | |
Unknown | 66 | 28 (42.4) | 1.44 (0.91 - 2.26) | Â | |
Hypertension | No | 468 | 122 (26.1) | 1.00 | 1.00 |
Yes | 198 | 68 (34.3) | 1.54 (1.11 - 2.12) | 1.49 (1.06 - 2.10) | |
Diabetes | No | 607 | 174 (28.7) | 1.00 | Â |
Yes | 59 | 16 (27.1) | 0.96 (0.57 - 1.62) | Â | |
Arthritis | No | 480 | 135 (28.1) | 1.00 | Â |
Yes | 186 | 55 (29.6) | 1.19 (0.86 - 1.65) | Â | |
Charlson Comorbidity Index | 0 | 599 | 177 (29.6) | 1.00 | Â |
1-2 | 65 | 13 (20.0) | 0.70 (0.40 - 1.24) | Â | |
Missing | 2 | 0 (0.0) | - | Â | |
Hormonal factors | Â | Â | Â | Â | Â |
Oral contraceptives use prior to diagnosis | No | 189 | 48 (25.4) | 1.00 | Â |
Yes | 477 | 142 (29.8) | 1.12 (0.79 - 1.58) | Â | |
Estrogen use prior to diagnosisd,e | No | 120 | 26 (21.7) | 1.00 | Â |
Yes | 210 | 52 (24.8) | 1.36 (0.83 - 2.24) | Â | |
Missing | 11 | 2 (18.2) | - | Â | |
Progestin use prior to diagnosisd,e | No | 205 | 52 (25.4) | 1.00 | Â |
Yes | 119 | 23 (19.3) | 0.94 (0.56 - 1.59) | Â | |
Missing | 17 | 5 (29.4) | - | Â | |
Lifestyle factors | Â | Â | Â | Â | Â |
Pack-years of smoking | <100 cigarettes in lifetime, <0.05 pack-years | 326 | 92 (28.2) | 1.00 | Â |
0.05-5.3 pack-years | 112 | 33 (29.5) | 1.06 (0.71 - 1.58) | Â | |
5.4-20.5 pack-years | 111 | 37 (33.3) | 1.31 (0.89 - 1.93) | Â | |
>20.5 pack-years | 114 | 27 (23.7) | 0.93 (0.60 - 1.44) | Â | |
Missing | 3 | 1 (33.3) | - | Â | |
Per pack-year of smoking | Â | Â | 1.00 (0.99 - 1.01) | Â | |
 |  |  | P trend = 0.47 |  | |
Alcohol intake year prior to diagnosis (grams per day) | <1 | 329 | 102 (31.0) | 1.00 | Â |
1-6 | 99 | 25 (25.3) | 0.82 (0.52 - 1.28) | Â | |
>6 | 117 | 29 (24.8) | 0.94 (0.61 - 1.45) | Â | |
Missing | 121 | 34 (28.1) | 1.28 (0.79 - 2.09) | Â | |
Per gram of alcohol | Â | Â | 0.99 (0.97 - 1.01) | Â | |
 |  |  | P trend = 0.42 |  | |
Sports and recreational activities year prior to diagnosis (MET hours/week) | <0.5 | 223 | 68 (30.5) | 1.00 | Â |
0.5-20.0 | 298 | 85 (28.5) | 1.13 (0.80 - 1.59) | Â | |
>20.0 | 144 | 37 (25.7) | 1.09 (0.71 - 1.67) | Â | |
Missing | 1 | 0 (0.0) | - | Â | |
Per MET hour | Â | Â | 1.00 (0.99 - 1.01) | Â | |
 |  |  | P trend = 0.80 |  |