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Table 2 Linear regression of factors associated with telomere length

From: Physical activity and telomere length in early stage breast cancer survivors

  Univariate analysis Multivariate analysis
Coefficient (95% CI) P Adjusted coefficient (95% CI) P
Physical activity     
  Moderate to vigorous (reference) 1   1  
  None −0.27 (−0.08, −0.46) 0.006 −0.22 (−0.41, −0.03) 0.03
Age, years     
  <55 (reference) 1   1  
  55 to 65 −0.12 (−0.30, 0.07) 0.22 −0.09 (−0.28, 0.10) 0.33
  >65 −0.33 (−0.52, −0.13) 0.001 −0.26 (−0.47, 0.04) 0.02
Body mass index     
  <25 a1    
  25 to 30 −0.01 (−0.19, 0.16) 0.88   
  >30 −0.13 (−0.031, 0.05) 0.16   
Smoking status     
  Never (reference) 1    
  Current −0.11 (−0.52, 0.30) 0.60   
  Previous −0.09 (−0.24, 0.06) 0.22   
Race/ethnicity     
  White a1    
  Non-white* −0.03 (−0.22, 0.16) 0.74   
Educational level     
  High school or less a1    
  College 0.07 (−0.12, 0.26) 0.48   
  Graduate or higher 0.16 (−0.04, 0.36) 0.11   
Marital status     
  Married/partnered a1    
  Single −0.02 (−0.18, 0.13) 0.76   
Stage     
  0 and I (reference) 1    
  II 0.04 (−0.11, 0.20) 0.58   
  III 0.06 (−0.18, 0.31) 0.60   
Previous chemotherapy     
  No chemotherapy (reference) 1   1  
  Chemotherapy 0.19 (0.04, 0.34) 0.01 0.07 (−0.09, 0.24) 0.38
Current aromatase inhibitor     
  None (reference)     
  Letrozole 0.09 (−0.19, 0.38) 0.53   
  Anastrozole −0.01 (−0.26, 0.23) 0.93   
  Exemestane 0.03 (−0.28, 0.34) 0.84   
Cormorbid conditions     
  None (reference) 1    
  One −0.02 (−0.25, 0.21) 0.86   
  Two or more −0.11 (−0.32, 0.10) 0.29   
Anxiety     
  Normal (reference) 1    
  Symptomatic −0.01 (−0.18, 0.16) 0.93   
Depression     
  Normal (reference) 1    
  Symptomatic 0.05 (−0.21, 0.31) 0.70   
  1. *Mostly Black; hospital anxiety and depression scale (HADS) anxiety and depression categorization: normal = 0 to 7; symptomatic = 8 to 21. Covariates with P-values <0.10 in the univariate analyses were carried forward to the respective multivariate models. P-values in boldface type are statistically significant.