Skip to main content

Table 2 Linear regression of factors associated with telomere length

From: Physical activity and telomere length in early stage breast cancer survivors

 

Univariate analysis

Multivariate analysis

Coefficient (95% CI)

P

Adjusted coefficient (95% CI)

P

Physical activity

    

  Moderate to vigorous (reference)

1

 

1

 

  None

−0.27 (−0.08, −0.46)

0.006

−0.22 (−0.41, −0.03)

0.03

Age, years

    

  <55 (reference)

1

 

1

 

  55 to 65

−0.12 (−0.30, 0.07)

0.22

−0.09 (−0.28, 0.10)

0.33

  >65

−0.33 (−0.52, −0.13)

0.001

−0.26 (−0.47, 0.04)

0.02

Body mass index

    

  <25

a1

   

  25 to 30

−0.01 (−0.19, 0.16)

0.88

  

  >30

−0.13 (−0.031, 0.05)

0.16

  

Smoking status

    

  Never (reference)

1

   

  Current

−0.11 (−0.52, 0.30)

0.60

  

  Previous

−0.09 (−0.24, 0.06)

0.22

  

Race/ethnicity

    

  White

a1

   

  Non-white*

−0.03 (−0.22, 0.16)

0.74

  

Educational level

    

  High school or less

a1

   

  College

0.07 (−0.12, 0.26)

0.48

  

  Graduate or higher

0.16 (−0.04, 0.36)

0.11

  

Marital status

    

  Married/partnered

a1

   

  Single

−0.02 (−0.18, 0.13)

0.76

  

Stage

    

  0 and I (reference)

1

   

  II

0.04 (−0.11, 0.20)

0.58

  

  III

0.06 (−0.18, 0.31)

0.60

  

Previous chemotherapy

    

  No chemotherapy (reference)

1

 

1

 

  Chemotherapy

0.19 (0.04, 0.34)

0.01

0.07 (−0.09, 0.24)

0.38

Current aromatase inhibitor

    

  None (reference)

    

  Letrozole

0.09 (−0.19, 0.38)

0.53

  

  Anastrozole

−0.01 (−0.26, 0.23)

0.93

  

  Exemestane

0.03 (−0.28, 0.34)

0.84

  

Cormorbid conditions

    

  None (reference)

1

   

  One

−0.02 (−0.25, 0.21)

0.86

  

  Two or more

−0.11 (−0.32, 0.10)

0.29

  

Anxiety

    

  Normal (reference)

1

   

  Symptomatic

−0.01 (−0.18, 0.16)

0.93

  

Depression

    

  Normal (reference)

1

   

  Symptomatic

0.05 (−0.21, 0.31)

0.70

  
  1. *Mostly Black; hospital anxiety and depression scale (HADS) anxiety and depression categorization: normal = 0 to 7; symptomatic = 8 to 21. Covariates with P-values <0.10 in the univariate analyses were carried forward to the respective multivariate models. P-values in boldface type are statistically significant.